Nano silica/polydopamine adhesive hemostatic material for external use and preparation method thereof

A technology of nano-silicon dioxide and polydopamine, which is applied in the field of biomedical hemostatic materials, can solve the problems of low safety performance, weak wet adhesion and the like, and achieves the effects of low cost, improved hemostatic performance and convenient application.

Active Publication Date: 2018-05-08
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Combat Gauze, a military kaolin product, has solved the exothermic and peripheral embolism problems of the previous two generations of products (QuickClot and WoundStat), kaolin hemostatic materials also have the disadvantage of weak wet adhesion and are only suitable for light and moderate bleeding; Although the mesoporous silicon material has excellent hemostatic properties, it is found that it has local vascular embolism similar to WoundStat, and its safety performance is low

Method used

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  • Nano silica/polydopamine adhesive hemostatic material for external use and preparation method thereof
  • Nano silica/polydopamine adhesive hemostatic material for external use and preparation method thereof
  • Nano silica/polydopamine adhesive hemostatic material for external use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In 100mL of tetramethylethylenediamine or tetramethylguanidine dilute alkali solution with pH=7.0, add 2.00g of nano-SiO 2 and 0.04g dopamine, sonicated for 10min, and reacted at room temperature for 12h; the product was freeze-dried for 6h to obtain SiO 2 / PDA nano-network composite material. Depend on figure 1 (a) (50:1) SiO 2 / PDA transmission electron microscope shows that the prepared SiO 2 / PDA nano-network composite material.

Embodiment 2

[0028] In 100mL of triethylamine or triethylenediamine dilute alkali solution with pH=8.0, add 2.00g of nano-SiO 2 and 0.10g dopamine, sonicated for 10min, and reacted at room temperature for 18h; the product was freeze-dried for 12h to obtain SiO 2 / PDA nano-network composite material. Depend on figure 1 (a) (30:1) SiO 2 / PDA transmission electron microscope shows that the prepared SiO 2 / PDA nano-network composite material.

Embodiment 3

[0030] In 100mL of 2-amino-2-(hydroxymethyl)-1,3-propanediol or N-methylmorpholine dilute alkali solution with pH=9.0, add 2.00g of nano-SiO 2 and 0.20g dopamine, sonicated for 10min, and reacted at room temperature for 24h; the product was freeze-dried for 18h to obtain SiO 2 / PDA nano-network composite material. Depend on figure 1 (a) (10:1) SiO 2 / PDA transmission electron microscope shows that the prepared SiO 2 / PDA nano-network composite material.

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Abstract

The invention discloses a nano silica/polydopamine adhesive hemostatic material for external use and a preparation method thereof. Nano silica and dopamine are used as raw materials, and a certain proportion of the nano silica and the dopamine are added into a dilute alkali solution (a mass ratio ranges from (50 : 1) to (5 : 1)), a reaction is carried out at room temperature for 12 to 36 h; a product is freeze-dried to prepare an SiO2/PDA nano meshed composite material. The SiO2/PDA nano meshed composite material obtained by the preparation method has very good adhesion performance to different substrates and has strong adhesion performance to blood at the same time.

Description

technical field [0001] The invention relates to an external-use nano silicon dioxide / polydopamine adhesive hemostatic material and a preparation method thereof, belonging to the technical field of biomedical hemostatic materials. Background technique [0002] Uncontrolled bleeding is considered to be the primary cause of death in surgical operations, accidents, and war scenes. Therefore, emergency life-saving hemostatic materials have become a research hotspot. In a short period of time (about 2-5 minutes) efficient and rapid control or greatly reduced aortic bleeding will buy valuable time for further pre-hospital first aid. The main characteristics of uncontrolled bleeding are large blood volume and deep and irregular wounds. Therefore, hemostatic materials are required to quickly and strongly adhere to the wound surface to seal the wound in a humid environment, and at the same time, safe, efficient and rapid coagulation reactions occur. [0003] Strong adhesion of hemost...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/06
CPCA61L24/0015A61L24/0068A61L2300/20A61L2300/402A61L2300/404A61L2300/412A61L2400/04C08L79/04
Inventor 乔卫红柳春玉田萌魏骏楠傅昱
Owner DALIAN UNIV OF TECH
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