Method for implementing single-molecule chemical reaction network by DNA (deoxyribonucleic acid) strand displacement reaction

A chemical reaction network and DNA chain technology, applied in the field of single-molecule chemical reaction network, can solve the problem of high complexity and achieve the effect of reducing complexity

Active Publication Date: 2018-05-08
SOUTHEAST UNIV
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Such complexity is ac

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  • Method for implementing single-molecule chemical reaction network by DNA (deoxyribonucleic acid) strand displacement reaction
  • Method for implementing single-molecule chemical reaction network by DNA (deoxyribonucleic acid) strand displacement reaction
  • Method for implementing single-molecule chemical reaction network by DNA (deoxyribonucleic acid) strand displacement reaction

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Embodiment Construction

[0019] The technical solution of the present invention will be further introduced below in combination with specific implementation methods and accompanying drawings.

[0020] This specific embodiment discloses a method for realizing a chemical reaction network in the form of a single molecule by DNA strand displacement reaction, such as figure 1 shown, including the following steps:

[0021] S1: Represent a form of chemical reaction substances with DNA strands with the same label, such as figure 2 As shown, each marker includes a short chain and a long chain, and each marker uniquely determines a form of reactant. All DNA strands with the same marker sequence, even if the sequence of the historical strand "?" Form reactants;

[0022] S2: if figure 2 As shown, a DNA strand displacement reaction is used to map an irreversible single-molecule chemical reaction, and two DNA strand displacement reactions are used to map a reversible single-molecule chemical reaction; the form...

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Abstract

The invention discloses a method for implementing a single-molecule chemical reaction network by DNA (deoxyribonucleic acid) strand displacement reaction. The method includes the steps: S1 expressingone chemical reaction substance by the aid of DNA strands with same marks; S2 mapping one irreversible single-molecule chemical reaction by the aid of one DNA strand displacement reaction, and mappingone reversible single-molecule chemical reaction by the aid of two DNA strand displacement reactions; S3 setting a rate constant of the corresponding DNA reaction according to the a rate constant ofthe chemical reaction; S4 adjusting the rate of the strand displacement reaction according to the matched degree of a short strand in mark strands and a complementary strand of the short strand; S5 simulating dynamic characteristics of the chemical reaction network by the aid of dynamic characteristics of a DNA network formed by all DNA strand displacement reactions. Each mark comprises a short strand and a long strand, a reaction network formed by a plurality of chemical reactions is a chemical reaction network, and the chemical reaction of the corresponding DNA strand reaction multiplies initial concentration of an auxiliary strand to be equal to the rate constant of the chemical reaction.

Description

technical field [0001] The invention relates to the field of molecular calculation, in particular to a method for realizing a chemical reaction network in the form of a single molecule by using a DNA strand displacement reaction. Background technique [0002] Traditional computers mainly use silicon-based circuits. According to Moore's Law, the development of silicon-based chips has reached its peak in recent years. Due to the tunneling effect of silicon-based materials smaller than 5nm, Moore's Law is no longer applicable. Therefore, new computing methods and materials have received extensive attention from researchers. In the existing research at home and abroad, molecular computing, as a field with great potential, has achieved a lot of results. Because the chemical reaction network can express various dynamic characteristics, it is regarded as a programmable language by many researchers to realize various calculation modules such as digital circuits, analog circuits an...

Claims

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Application Information

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IPC IPC(8): G06F19/00
CPCG16C10/00G16C20/10
Inventor 张川沈梓原尤肖虎
Owner SOUTHEAST UNIV
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