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Carbon monoxide releasing material based on carbon nanotubes and preparation method thereof

A technology of carbon nanotubes and release materials, applied in chemical instruments and methods, medical preparations of non-active ingredients, pharmaceutical formulations, etc., can solve problems such as poor response to infrared light radiation, achieve safe and slow release, reduce residues, Solve the effect of residual heavy metal ions

Active Publication Date: 2020-11-27
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of existing carbon monoxide releasing materials, such as poor infrared radiation response and toxic heavy metal residues, and provide a carbon monoxide releasing material based on carbon nanotubes. Carbon nanotubes have unique optical properties that can effectively improve Infrared photoresponse of ruthenium carbonyl, at the same time, functionalized carbon nanotubes can effectively bind metal ions and inhibit the dissolution of metals, thereby reducing the biological toxicity of the entire material

Method used

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  • Carbon monoxide releasing material based on carbon nanotubes and preparation method thereof
  • Carbon monoxide releasing material based on carbon nanotubes and preparation method thereof
  • Carbon monoxide releasing material based on carbon nanotubes and preparation method thereof

Examples

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Effect test

Embodiment 1

[0018] Weigh 50 mg CORM-2 and dissolve it in 6 mL dimethyl sulfoxide, add 100 mg carbon nanotubes, stir magnetically for 3 hours, let stand at room temperature until dimethyl sulfoxide is completely volatilized, wash once with dimethyl sulfoxide, centrifuge, and wash with absolute ethanol Wash twice, centrifuge, and dry to obtain carbon monoxide releasing materials (CO-CNTs) based on carbon nanotubes.

[0019] Gained material is characterized by infrared, transmission and XRD, the results are shown in Figure 1~4 . figure 1 Medium 2375.39cm -1 with 2341.55cm -1 Corresponding to the three carbonyl peaks on the CORM-2 molecule, figure 2 The CORM-2 molecules loaded on the carbon nanotubes can be clearly seen, image 3 The bright dots in the figure are CORM-2 molecules, and the CORM-2 molecules loaded on the carbon nanotubes can also be clearly seen. Figure 4 The two sharp peaks at 14° and 15° are the lattice peaks of CORM-2.

[0020] It is calculated that 1 mg of the CO-C...

Embodiment 2

[0022] Weigh 100mg CORM-2 and dissolve it in 12mL tetrahydrofuran, add 50mg carbon nanotubes, stir magnetically for 3h, let stand at room temperature until tetrahydrofuran is completely volatilized, wash once with tetrahydrofuran, centrifuge, wash twice with absolute ethanol, centrifuge, and dry to obtain Carbon monoxide releasing materials based on carbon nanotubes (CO-CNTs).

[0023] Depend on Image 6 It can be seen that when the concentration of the CO-CNTs material prepared in this example is 0.6 mg / μL, the amount of CO released is 9.64753 μmol / L (23.68 μL); when the concentration is 1.2 mg / μL, the amount of CO released is 10.47938 μmol / L (25.72μL); when the concentration is 1.8mg / μL, the amount of CO released is 22.87949μmol / L (56.15μL).

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Abstract

The invention discloses a carbon nano-tube-based carbon monoxide releasing material and a preparation method thereof. The releasing material consists of a carbon nano-tube-loaded ruthenium carbonyl lead structure [CORM-2], and is characterized by being capable of effectively responding to infrared light radiation to release carbon monoxide in a sustained manner. The material preparation method adopted by the invention is simple, and can realize large-scale production. A myoglobin immunity experiment discovers that the releasing material is sensitive in light response and can exist stably in anin-vitro physiological environment; a carrier, namely, the carbon nano-tube structure, of the releasing material can effectively adsorb heavy metal ions produced after releasing, so that potential toxicity caused by the heavy metal ions which remain in a living body is reduced, and a key material is provided for carbon monoxide medical treatment.

Description

technical field [0001] The invention belongs to the technical field of carbon monoxide releasing materials, and specifically relates to the preparation and synthesis of a safe, non-toxic and portable carbon nanotube with a high specific surface area that responds to near-infrared light excitation and has the ability to adsorb heavy metals as a controllable release carrier. A therapeutic dose of carbon monoxide releasing material. Background technique [0002] In recent years, research on the physiological activity and therapeutic application of endogenous CO has made great progress. CO has a significant therapeutic effect in pre-clinical trials of cardiovascular expansion, organ transplantation, antipyretic and anti-inflammation, etc. However, CO is a gas molecule, and it is difficult to accurately control its dosage to the organ or tissue where the source of the disease is located; at the same time, CO will be strongly combined with hemoglobin, and high concentrations of C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/20B01J20/30A61K47/04
CPCA61K47/02B01J20/205B01J20/30
Inventor 张伟强李晶晶张晓刘晓张霞丽谢遵园张国防高子伟
Owner SHAANXI NORMAL UNIV
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