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Carbon monoxide releasing material based on natural clay and its preparation method

A carbon monoxide and natural clay technology, applied in chemical instruments and methods, medical preparations with inactive ingredients, pharmaceutical formulas, etc., can solve problems such as heavy metal residues, and achieve the effects of safe and slow-acting release, reduction of residues, and simple preparation methods.

Inactive Publication Date: 2015-12-30
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the heavy metal residue problem existing in the existing carbon monoxide release materials, provide a method that can effectively control the release of CO, and can absorb heavy metal ions while transporting CO, reducing the residue of heavy metal ions in the living body. Natural clay-based carbon monoxide release material for realizing safe and slow release of CO, and preparation method of the material

Method used

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  • Carbon monoxide releasing material based on natural clay and its preparation method
  • Carbon monoxide releasing material based on natural clay and its preparation method
  • Carbon monoxide releasing material based on natural clay and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0020] 0.0585g RuCl 3 Add 20mL ethylene glycol monomethyl ether into the three-necked flask, RuCl 3 The molar ratio to ethylene glycol monomethyl ether is 1:900, pass N 2 After removing the air, CO gas was introduced at a speed of 2 bubbles / second, and the oil bath was heated to 80 °C under stirring conditions, and the reaction was refluxed for 35 minutes. Soil, the amount of sodium montmorillonite added is RuCl 3 20 times the mass of the solution, and the reaction was continued at 80°C for 30 minutes. The color of the solution turned into egg yellow, and the heating was stopped, cooled to room temperature, and spin-dried on a rotary evaporator to obtain 1.1201g of a light gray-green carbon monoxide releasing material based on natural clay. Sealed and stored at low temperature.

[0021] The prepared carbon monoxide releasing materials based on natural clay were characterized by infrared spectroscopy and environmental scanning electron microscopy, respectively, and the resul...

Embodiment 2

[0025] 0.0481g RuCl 3 Add 20mL ethylene glycol ether into a three-necked flask, RuCl 3 The molar ratio to ethylene glycol ether is 1:900, pass N 2 After removing the air, CO gas was introduced at a rate of 2 bubbles / second, and the oil bath was heated to 80 °C under stirring conditions, and the reaction was refluxed for 35 minutes. The solution turned from brown to blood red. The amount of sodium montmorillonite added is RuCl 3 20 times the mass, then heated to 135°C, refluxed for 30 minutes, the solution turned egg yellow, stopped heating, cooled to room temperature, and spin-dried on a rotary evaporator to obtain a light gray-green carbon monoxide releasing material based on natural clay 1.0247 g, sealed and stored at low temperature.

[0026] The prepared carbon monoxide releasing materials based on natural clay were characterized by infrared spectroscopy and environmental scanning electron microscopy, respectively, and the results are shown in Figures 3 to 4 and Table...

Embodiment 3

[0028] 0.0325g RuCl 3 Add 20mL ethylene glycol monomethyl ether into the three-necked flask, RuCl 3 The molar ratio with ethylene glycol monomethyl ether is 1:500, pass N 2 After removing the air, CO gas was introduced at a speed of 2 bubbles / second, and the oil bath was heated to 70 °C under stirring conditions, and the reaction was refluxed for 60 minutes. Soil, the amount of calcium montmorillonite added is RuCl 315 times the mass of the solution, continue to reflux at 70°C for 60 minutes, the color of the solution turns egg yellow, stop heating, cool to room temperature, spin dry on a rotary evaporator to obtain a light gray-green carbon monoxide release material based on natural clay, sealed at low temperature save.

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Abstract

The invention discloses a natural clay based carbon monoxide release material and a preparation method thereof. Clay with hydrophilcity, swelling property and high-efficiency adsorbability to heavy metal material is used as a controllable release carrier to carry a ruthenium carbonyl specie Ru(CO)2Cl2 or (Ru(CO)3Cl2)2 so as to obtain the natural clay based carbon monoxide release material. The preparation method is simple, the obtained carbon monoxide release material can effectively control CO release, can reach the purpose of transferring CO and also can adsorb heavy metal ions released by the ruthenium carbonyl specie by use of the absorption action of clay during CO transferring, so as to reduce residue of heavy metal ions in a biological body, realize safe and slow CO release of a biological system and solve the difficult problem of heavy metal ion residue after transition metal carbonyl compound is released.

Description

technical field [0001] The invention belongs to the technical field of carbon monoxide releasing materials, and in particular relates to a method for preparing and synthesizing a kind of natural mineral-based material with slow-release effect and high-efficiency adsorption by in-situ carbonylation by utilizing the hydrophilicity, swelling properties of clay and high-efficiency adsorption of heavy metal materials. Carbon monoxide releasing material that adsorbs heavy metal ions. Background technique [0002] In recent years, great progress has been made in the therapeutic application of CO physiological activity, especially for cardiovascular dilation, organ transplantation, antipyretic resistance and other treatments. CO has a remarkable therapeutic effect in preliminary clinical trials. Although CO has potential medical effects, there are many limitations in medical application. CO is a gas molecule, and it is difficult to accurately control its amount and timing, and it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/12B01J20/30A61K47/04A61K33/24
Inventor 张伟强杨淑红贺文斌王候芳杨金娥黄艳宁张倩杨艳艳
Owner SHAANXI NORMAL UNIV
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