A kind of colistin sulfate soluble powder and preparation method thereof

A colistin sulfate, soluble technology, applied in the field of colistin sulfate soluble powder and its preparation, can solve the problems affecting the efficacy of colistin sulfate, economic loss in breeding industry, dehydration and death of piglets, etc., and is beneficial to large-scale production The effects of production and marketing, wide range of medication methods, and low cost

Active Publication Date: 2021-06-11
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both are acute infectious diseases of newborn piglets caused by pathogenic Escherichia coli. If not treated in time, it is easy to cause dehydration and death of piglets, which will bring huge economic losses to the breeding industry
[0004] Colistin sulfate is easily soluble in water and has hygroscopicity. It is easy to agglomerate under high temperature and high humidity conditions, which will affect the efficacy of colistin sulfate. This problem has always been a difficult problem in the research of colistin sulfate preparations.

Method used

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  • A kind of colistin sulfate soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A colistin sulfate soluble powder, comprising the following raw materials in parts by weight: 10-30 parts of colistin sulfate, 10-30 parts of β-cyclodextrin, 2-5 parts of polyethylene glycol 6000, and 35-78 parts of sucrose share.

[0022] The preparation method of described colistin sulfate soluble powder, its preparation steps are:

[0023] (1) Weigh the raw materials of each component by weight percentage;

[0024] (2) First mix colistin sulfate and β-cyclodextrin, then add polyethylene glycol 6000, mix well, crush or grind finely;

[0025] (3) Add sucrose, mix well in a mixer, pass through a 40-80 mesh sieve to obtain colistin sulfate soluble powder.

Embodiment 2

[0027] A colistin sulfate soluble powder comprises the following raw materials in parts by weight: 15 parts of colistin sulfate, 15 parts of beta-cyclodextrin, 2 parts of polyethylene glycol 6000, and 68 parts of sucrose.

[0028] The preparation method of described colistin sulfate soluble powder, its preparation steps are:

[0029] (1) Weigh the raw materials of each component by weight percentage;

[0030] (2) First mix colistin sulfate and β-cyclodextrin, then add polyethylene glycol 6000, mix well, crush or grind finely;

[0031] (3) Add sucrose, mix evenly in a mixer, and pass through a 60-mesh sieve to obtain colistin sulfate soluble powder.

Embodiment 3

[0033] A colistin sulfate soluble powder comprises the following raw materials in parts by weight: 10 parts of colistin sulfate, 15 parts of beta-cyclodextrin, 5 parts of polyethylene glycol 6000 and 70 parts of sucrose.

[0034] The preparation method of described colistin sulfate soluble powder, its preparation steps are:

[0035] (1) Weigh the raw materials of each component by weight percentage;

[0036] (2) First mix colistin sulfate and β-cyclodextrin, then add polyethylene glycol 6000, mix well, crush or grind finely;

[0037] (3) Add sucrose, mix well, and pass through a 40-mesh sieve to obtain colistin sulfate soluble powder.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations. The invention provides colistin sulfate soluble powder with good water solubility, high stability, simple preparation process, good effect in treating bacterial diseases of livestock and poultry, and convenient use and a preparation method thereof. A colistin sulfate soluble powder, comprising the following raw materials in parts by weight, 10-30 parts of colistin sulfate, 10-30 parts of β-cyclodextrin, 2-5 parts of polyethylene glycol 6000, 35-78 parts of sucrose share. In the colistin sulfate soluble powder provided by the present invention, the raw material β-cyclodextrin is a stabilizer, which is slightly soluble in water, does not have hygroscopicity, and is easy to form stable hydrates, which can well solve the problem of colistin sulfate The problem of caking under high temperature and high humidity conditions. Polyethylene glycol 6000 is a cosolvent, which can increase the solubility of colistin sulfate in water. The preparation process of the present invention is less, the operation is simple, the stability is good, the cost is low, the storage is convenient, and it is beneficial to large-scale production and market promotion. It is convenient to take and has a wide range of medication methods, such as mixed feeding, mixed drinking and as an additive.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a colistin sulfate soluble powder and a preparation method thereof. Background technique [0002] Colistin sulfate is white or light yellow powder, easily soluble in water. Colistin sulfate has a strong inhibitory effect on Gram-negative bacteria and belongs to the class of polypeptide antibacterial drugs. The positively charged free amino groups of colistin sulfate can combine with the negatively charged phosphate radicals in the phospholipids of the cytoplasmic membrane of Gram-negative bacilli, thereby reducing the surface tension of the cytoplasmic membrane and increasing its permeability. , purine, amino acid and phosphate and other components leak out; at the same time, the drug can also enter the cytoplasm, infect the normal function of bacteria, and cause the death of bacteria. Bacteria sensitive to colistin sulfate mainly include Brucell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/12A61K9/14A61K47/40A61K47/10A61P31/04
CPCA61K9/146A61K38/12
Inventor 徐进刘梅金喜新许贤会魏志刚梁桂霞
Owner ZHENGZHOU HOUYI PHARMA
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