Improved tetrandrine extraction method

An extraction method, the technology of tetrandrine, applied in the direction of organic chemistry, can solve the problems of difficult recovery of alkaloids, lower extraction rate, large solvent loss, etc., and achieve the effects of high efficiency, enhanced release, and easy production

Inactive Publication Date: 2018-06-29
ANHUI CHINATURE BIOLOGICAL CO LTD
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Problems solved by technology

Method 1 produces a large amount of waste water, tetrandrine is difficult to completely precipitate and the extrac...

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Embodiment Construction

[0014] The following clearly and completely describes the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0015] An improved extraction method of tetrandrine, comprising the following steps:

[0016] a. Pulverize the Fangji medicinal material, pass through a 100-mesh sieve, add 2-5% quicklime and soak in ethanol, reflux extraction for 2-3 hours, and filter to obtain the extract;

[0017] b. Put the extraction solution in an ultrasonic-microwave extraction device, the ultrasonic wave is 500W, the microwave power is 400~500W, and the extraction time is 60~90min;

[0018] c. Centrifuge the above-mentioned extract, take the supernatant, co...

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Abstract

The invention discloses an improved tetrandrine extraction method, which comprises the following technical steps: carrying out high-concentration ethyl alcohol alkalifying extraction, carrying out acid dissolution, carrying out D72 macropore cation exchange resin separation, carrying out methylbenzene extraction, and carrying out alternating crystallization on acetone and ethyl alcohol to obtain aproduct. According to the extraction method, the cavatition effect of ultrasonic wave is used for breaking the cells of plant medicines, and therefore, a solvent can easily penetrate into cells. Meanwhile, the strong vibration of the ultrasonic wave can be used for transferring huge energy to leached medicines and solvent to enable the medicines and the solvent to move at a high speed, and the releasing, the diffusion and the dissolving of intracellular substances can be enhanced. Compared with a traditional extraction method, the method has the advantages of high efficiency, high selectivity, simpleness in operation, high yield and the like, and a product can be easily purified.

Description

technical field [0001] The invention relates to the extraction technology of tetrandrine, in particular to an improved extraction method of tetrandrine. Background technique [0002] Fangji has another name called powder Fangji, Han Fangji, and stone toad, which is the dry root of the perennial twining vine of Fangjiaceae, Stephaniatetrandra S. Moore. Bitter in the mouth, it has the effect of diuresis, detumescence, dispelling wind and relieving pain. For edema beriberi, dysuria, eczema sores, rheumatic arthralgia and hypertension (Pharmacopoeia of the People's Republic of China 2005 edition one, P101-102). Modern studies have found that Tetradendron alkaloids have various pharmacological effects such as antiarrhythmia, antimyocardial, cerebral, and renal ischemia, antihypertension, anti-inflammation, and anti-tumor multidrug resistance (Chinese Journal of Pharmaceutical Sciences, 2000, 35, P800 -802). Alkaloids are mainly tetrandrine (also known as Tetrandrine, content...

Claims

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Application Information

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IPC IPC(8): C07D491/18
CPCC07D491/18
Inventor 储浩侠
Owner ANHUI CHINATURE BIOLOGICAL CO LTD
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