Synthetic method of acylated quinoline or isoquinoline derivatives

A technology for acylation of quinolines and synthetic methods, applied in the direction of organic chemistry, etc., can solve problems such as complex reactions, poor environmental protection, and harsh conditions, and achieve the effects of simple reaction conditions, wide application range, and simple and convenient operation
CN108299291BActive Publication Date: 2019-11-22杭州量创科技咨询有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
杭州量创科技咨询有限公司
Publication Date
2019-11-22

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Abstract

The invention discloses a synthesis method of an acylated quinoline or isoquinoline derivative, belongs to the field of organic synthesis, and aims to solve the problems of complicated reaction, severe conditions and low environmental friendliness in the conventional acylated quinoline or isoquinoline derivative synthesis method. The synthesis method comprises the following steps: under a nitrogenatmosphere, adding quinoline or isoquinoline and benzoyl formic acid which are used as reaction raw materials, persulfate used as an oxidant and a metal iridium compound used as a visible light catalyst into a reaction container together with an organic solvent for reaction under a visible light illumination condition, and at the end of the reaction, filtering, concentrating, separating and purifying a reaction system, thus obtaining the acylated quinoline or isoquinoline derivative. According to the synthesis method, under the nitrogen atmosphere, the reaction system is placed under a visible light source for illumination to realize reaction, so that the whole reaction process is safe and environmentally friendly, reaction conditions are simple, and operation steps are convenient; the synthesis method belongs to an environment-friendly chemical process.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis, in particular to a method for synthesizing acylated (iso)quinoline derivatives. Background technique

[0002] (Iso)quinoline derivatives are a common and important class of nitrogen heterocyclic compounds. (Iso)quinoline compounds containing different functional groups can exhibit various biological and pharmacological activities, such as antibacterial, antiviral, Anti-malarial and anti-tumor, etc., have been widely used in the fields of medicine and pesticides. (Iso)quinoline derivatives can be directly extracted from various natural products. Papaverine (papaverine) as shown in the following structural formula is extracted from poppy. It contains an isoquinoline skeleton structure and has an analgesic effect. In addition, such derivatives can also be obtained by chemical synthesis. As shown in the following structural formula, Neratinib is a small molecule tyrosine kinase inhibitor with a quin...

Claims

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