A kind of preparation method of benzofuran compound

A compound and methyl technology, applied in the field of preparation of benzofuran compounds, can solve the problems of harsh conditions, complex preparation methods, poor environmental protection and the like, and achieve the effects of low cost, simple and convenient operation, and wide application range
CN105884724BActive Publication Date: 2018-09-14ZHEJIANG SHENGXIAO CHEM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG SHENGXIAO CHEM
Publication Date
2018-09-14

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Abstract

The invention provides a preparation method of a benzofuran compound. The method comprises the following steps of: in a nitrogen atmosphere and in the presence of persulfate and an organic solvent, enabling a p-methoxyphenol compound protected by a trimethylsilyl group to react with an aromatic olefin compound. The method provided by the invention has the advantages of simple start raw materials, no metal catalysis, mild reaction conditions and easiness in operation, is a green environment-friendly chemical technology and can be widely used for preparing benzofuran compounds; and the synthesis of a natural product corsifuran A can be finished in one step by the method.
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Description

technical field

[0001] The invention relates to a preparation method of benzofuran compounds. Background technique

[0002] Benzofuran compounds are a class of important heterocyclic compounds with diverse structures, which widely exist in natural products and synthetic drugs, and have potential biological activities and pharmacological properties, such as anti-inflammatory, anti-cancer, anti-oxidation and other physiological functions. Among them, the 2,3-dihydrobenzofuran skeleton represents the core structure of many biologically and pharmacologically active compounds, such as compounds 1-4 shown below, so more and more people are working on benzofuran compounds synthesis research.

[0003]

[0004] At present, there are many reports on the preparation of dihydrobenzofuran compounds, but there are still many shortcomings, for example, the reaction starting materials are complicated, multi-step synthesis is required, the reaction conditions are harsh, and metal catalys...

Claims

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