A method for synthesizing benzylamines by catalytic hydrogenation of imines

Abstract

A method for synthesizing benzylamine compounds by catalytic hydrogenation of imines belongs to the field of organic synthesis, and aims to solve the problems of high reaction cost, poor environmental protection and high reaction risk existing in the existing imine hydrogenation reduction synthesis method. Synthesis method: under nitrogen atmosphere, use imine as reaction raw material, thiophenol as hydrogen source, add organic visible light catalyst, use weak acid as co-catalyst, add reaction solvent together into reaction vessel, and carry out under visible light conditions reaction, after the reaction is completed, the reaction system is concentrated and separated and purified to obtain benzylamine derivatives; wherein the organic visible light catalyst is Eosin Y, Rhodamine B or fac-Ir(ppy) 3 . The reaction substrate of the invention has a wide application range, and the conversion of the substituent R in the reaction substrate can be used to realize the synthesis of differently substituted benzylamine derivatives. The whole reaction process is safe and environment-friendly, and the reaction conditions are simple.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a method for preparing benzylamine derivatives through hydrogenation reduction of imine compounds under the action of an organic non-metallic catalyst. Background technique [0002] Imine compounds are an important class of organic synthesis intermediates, which are widely used and studied in agronomy, medicine and fine chemistry. In recent years, the chemical reactions involving imine compounds have received extensive attention, and great progress has been made in organic synthesis. Among them, the hydrogenation reduction of the C=N bond in the imine chemical structure plays an important role in pesticides, medicines, fine chemicals and organic synthesis. The benzylamine compound obtained from the reduction is an important intermediate in organic synthesis, and has certain antibacterial and anti-inflammatory activities in pharmaceutical applications. [0003] Tradi...

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of high reaction cost, poor environmental protection and high reaction risk in the existing imine hydrogenation reduction synthesis method, and provide an organic catalytic imine hydrogenation reduction using water as the reaction solvent at normal temperature and pressure. A Novel Method for the Synthesis of Benzylamines

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