102 results about "Benzoylformic acid" patented technology

The invention discloses novel Multi-functionalized benzoylformicacid hydroxy-ketone ester compounds, phosphorus-acyl derivatives, a combination containing the compounds, and a photoinitiator being used for photopolymerization of an alkene unsaturated compound system and containing the compounds. The compounds contain at least one of compounds shown in the following general formula I-III or any combination comprising the compounds shown in the following general formula I-III. The compounds can be used as alkene unsaturated compounds or the photoinitiator or photopolymerization of a mixt6ure containing the compounds, and can be combined with another photoinitiator and/or other additives for use.

The invention discloses a synthesis method for 3 - aroyl indole compound with a formula I, which is characterized by comprising the following steps: taking R1-substituted indoles (II) and R2- substituted benzoylformic acid (III) as raw materials, copper salt as a catalyst, silver salt as an oxidant; and performing acylation reaction of decarboxylation in an organic solvent. According to the method, inexpensive and stable copper salt and silver salt are adopted; the reaction environment is not required to be subjected to absolute anhydrous processing; inert gas protection is not required, and the acylation reaction can be directly performed; and the reaction condition is mild and the yield is higher.

This invention discloses a method for producing optical pure chiral mandelic acid. Use methyl benzoyl formate or the derivative of phenylglyoxylic acid as the bottom thing, the microorganism's cell of yeasts or mould whitlying etc. as catalyst, alternatively reduces the carbonyl in the bottom thing to the hydroxyl to get the chiral mandelic acid relying mainly on a kind of type (usually as R a type). This invention adopts chemistry-biology combination craft , with low cost, the chiral purity is high, easy to realize production for industrialization, it is easy to popularize and apply.

The invention discloses 7 alpha-hydroxysteroid dehydrogenase as well as a coding gene and application thereof. An amino acid sequence of the 7 alpha-hydroxysteroid dehydrogenase provided by the invention is shown as SEQ ID NO. 1, and a nucleotide sequence of the 7 alpha-hydroxysteroid dehydrogenase gene is disclosed and shown as SEQ ID NO. 2. The 7 alpha-hydroxysteroid dehydrogenase can catalyze asubstrate taurocholic acid (TCA) to generate taurine 7-ketone cholic acid (T7K-CA), catalyze a substrate glycocholic acid (GCA) to generate glycine 7-ketone cholic acid (G7K-CA), catalyze a substratetaurochenodeoxycholic acid (TCDCA) to generate taurine 7-ketone lithocholic acid (T7K-LCA), catalyze a substrate glycochenodeoxycholic acid (GCDCA) to generate glycine 7-ketone lithocholic acid (G7K-LCA) and catalyze a substrate ethyl benzoylformate (EB) to generate ethyl 2-hydroxy-2-phenylacetate, and has better catalytic activity, has a catalytic activity to TCDCA, GCDCA and EB 10, 5, and 3 times that of sardinia clostridium 7 alpha-HSDH, correspondingly, and has great industrial application value.

The present invention discloses a benzoyl formic acid synthesis method comprising the following steps: styrene is used as a starting material for implementation of hydrogen peroxide catalytic epoxidation reaction to produce styrene oxide intermediate, alpha-Hydroxyphenylacetone is obtained by hydrolysis of styrene oxide, and the generated alpha-Hydroxyphenylacetone is further oxidized into the desired product benzoyl formic acid. Advantages of the method are that: by use of the method using a solid base for hydrogen peroxide catalytic oxidation of the styrene substrate to form a styrene oxide precursor material, the use of hydrobromic acid is avoided, industrial production reaction cleanability is improved, product preparation selectivity, overall yield and product purity are improved, reaction condition is mild, reaction time is short, the complexity of the reaction process is reduced and industrialization is easy.

The invention relates to the technical field of hydrogel and in particular relates to a method for preparing high-strength hydrogel. The method disclosed by the invention comprises the following steps: modifying the surface of montmorillonoid and polyvinyl alcohol by virtue of a silane coupling agent, forming a silanol group and carrying out a hydroxylation reaction; finally forming a polymolecular cover film on the surface of montmorillonoid and polyvinyl alcohol by the silane coupling agent, enabling phenol to enter the montmorillonoid and polyvinyl alcohol particle layer and carrying out apolymerization reaction, so that the interior of the hydrogel is effectively filled; performing cycle freezing and liquid nitrogen spray freezing for three times, so that the mechanical strength of the hydrogel is improved; and introducing 2-acrylamido-2-methyl propane-sulfonic acid, N,N-methylenebis acrylamide, methyl benzoylformate, gelatin, nano-fibers, modified quartz sand powder and deionizedwater mixture. By utilizing excellent mechanical properties of the gelatin, nano-fibers and modified quartz sand powder, the acting force is effectively dispersed, the mechanical strength of the hydrogel is further improved, and the high-strength hydrogel has wide application prospects.

The invention discloses a high-selectivity synthesis method of benzoyl formic acid, which comprises the following steps: oxidizing styrene, which serves as the raw material, in a H2O2/tetrabutylammonium bromide mixed system to generate alpha-bromophenethyl alcohol; oxidizing the generated alpha-bromophenethyl alcohol with H2O2 to generate alpha-bromoacetophenone; hydrolyzing the alpha-bromoacetophenone under alkaline conditions to generate alpha-hydroxyacetophenone; and oxidizing the alpha-hydroxyacetophenone with H2O2 to generate the target product benzoyl formic acid. In the invention, oxydol is used as an oxidant, and the byproduct is water, thereby reducing the generation of the organic byproducts and the discharge amount of inorganic salt (acid) waste water. Compared with other inorganic heavy metallic salt and inorganic mineral acid oxidization methods, the method disclosed by the invention enhances the cleanness of industrial preparation reaction, and reduces the environmental pollution. The invention enhances the product yield and purity: the yield is enhanced by nearly 13%, the total yield is up to 93.7%, and the product purity exceeds 95%; and other indexes are correspondingly enhanced.

The invention provides a method for co-producing L-phenylglycine and gluconate through single expression and co-expression of glucose dehydrogenase and L-leucine dehydrogenase in escherichia coli through utilizing a recombinant escherichia coli enzyme method and a whole cell method. The method is as follows: a glucose dehydrogenase gene and an L-leucine dehydrogenase gene are used for constructing recombinant single expression and co-expression carriers and are transformed into a gene engineering bacterium, namely the escherichia coli. The circulation of cofactors in a transformation system can be promoted through utilizing a recombinant bacterium enzyme method and the whole cell method; only a few of exogenous cofactors are added or the exogenous cofactors do not need to be used, and the L-phenylglycine and gluconic acid, which have high additional value, are co-produced by substrates including benzoylformic acid and glucose through utilizing a cofactor cyclic regeneration system; a transformation process is simple and rapid and low in cost. When transformation is carried out in a 5L fermentation tank for 2h to 4h, the yields of the L-phenylglycine and the gluconic acid, obtained by the method, can respectively reach 58.8g/L and 75.6g/L, and an actual and effective strategy is provided for industrial production.

The invention provides a preparation method of (S)-(+)-ethyl mandelate by using biocatalytic ethyl benzoylformate and taking saccharomyces cerevisiae with CGMCC No.2266 as a biocatalyst. The method comprises the following steps of: performing a conversion reaction for 8 to 120 hours at a temperature of between 20 and 35 DEG C in a water and n-hexane two-phase system by using ethyl benzoylformate as a substrate and the saccharomyces cerevisiae with CGMCC No.2266 as a biocatalyst; and separating and purifying the conversion solution to obtain (S)-(+)-ethyl mandelate. The microbial conversion method has the advantages of mild reaction condition, friendly environment, high product optical purity, high substrate conversion rate, simple separation and purification process and recyclable catalyst, and is suitable for industrial production.

The invention relates to a method for synthesizing a novel industrial copper extracting agent. The method comprises the following steps of: 1, performing synthesis by taking acylating agents of straight-chain alkylbenzene, ethyl chloroformylformate and the like as raw materials through acylation reaction under the catalytic action of lewis acid or a solid acid catalyst to form para-alkyl benzoyl ethyl formate (a); and 2, performing synthesis on the para-alkyl benzoyl ethyl formate (a) synthesized by the step 1 and hydroxylamine hydrochloride by hydrolysis reaction and oximation reaction under the alkaline condition to form carboxylic oxime (which is a copper extracting agent). Compared with copper extracting agents which are used industrially at present, the industrial copper extracting agent synthesized by the method has the advantages that the industrial copper extracting agent can be used under the high-acidity condition, the extraction capacity, the degree of separation of copper and iron and the reextraction performance of the industrial copper extracting agent are superior or equal to the copper extracting agents, and the production cost of the industrial copper extracting agent is lower than that of hydroxyl oxime extracting agents. In addition, by the synthetic process, the requirements of energy conservation, consumption reduction and environment friendliness also can be met.

The invention discloses a preparation method of a-cyclopentyl methyl mandelate, comprising the following steps of: (1) Grignard reagent preparation of a-cyclopentyl chloride: performing a reaction between magnesium granules and cyclopentyl chloride in an ether or tetrahydrofuran solvent to generate an a-cyclopentyl chloride Grignard reagent; (2) preparation of an a-cyclopentyl methyl mandelate crude product: firstly dissolving benzoyl methyl formate in the ether or tetrahydrofuran solvent to form a benzoyl methyl formate solution, and performing a reaction between the a-cyclopentyl chloride Grignard reagent generated during the step (1) and the benzoyl methyl formate solution to generate the a-cyclopentyl methyl mandelate crude product; and (3) purification of the a-cyclopentyl methyl mandelate crude product: carrying out hydrolysis and esterification on the a-cyclopentyl methyl mandelate crude product obtained from the step (2) to obtain the pure a-cyclopentyl methyl mandelate. The raw materials of benzoyl methyl formate, magnesium granules and cyclopentyl chloride are all commonly-used reagents, have wide sources and are easy to obtain. In addition, the preparation method has advantages of simple steps for synthesis, low cost, low toxicity, convenient operation and high security.

The asymmetrical reduction bio-method for (R)-mandelic acid comprises: screening the Saccharomyces cerevisiae AS 2.150 for culture and full cell preparation; with benzoylformic aicd as substrate, adding assist substrate, catalytic converting to obtain the product with optical purity up to 90%e.e. This invention improves product optical purity and yield, and has important meaning for enzyme development and resolution.

The invention provides a method for preparing methyl (S)-(+)-mandelate by the microbial transformation of methyl benzoylformate. The method comprises the following steps of: performing transformation reaction at the temperature of 20 to 35 DEG C for 8 to 96 hours in dibutyl phthalate by taking methyl benzoylformate as a substrate, and enzyme-containing thallus cells obtained by fermenting a Saccharomyces cerevisiae strain CGMCC No.2230 as a biocatalyst, and separating and purifying a transformation solution to obtain a product, namely the methyl (S)-(+)-mandelate. Reaction conditions are mild, the microbial transformation method is environment-friendly and is suitable for industrialized production, the product has high optical purity, the substrate is high in transformation rate, the separation and purification process is simple, and the catalyst can be recycled.

The invention discloses a novel process for synthesizing methyl benzoylformate from benzoyl cyanide. The novel process comprises the following steps: dissolving benzoyl cyanide in an organic solvent, adding a halide catalyst and a phase transfer catalyst, lasting for 5-60 minutes at a temperature of 5-20 DEG C, adding dropwise concentrated sulfuric acid to the system, and carrying out thermal reaction for 0.5-5 hours at a temperature of 20-40 DEG C to obtain an intermediate iminosulfate compound; and lasting for 5-60 minutes at a temperature of 30-50 DEG C, adding dropwise methyl alcohol to the system, and carrying out thermal reaction for 0.5-5 hours at a temperature of 50-100 DEG C to obtain methyl benzoylformate. In the novel process disclosed by the invention, the reaction at a low temperature is accelerated obviously by using suitable solvents and composite catalysts, so that the potential safety hazard in industrialized production is eliminated, the stability of production is improved, the energy consumption is reduced, and the yield is up to 96%.

The invention discloses durable floor paint which comprises the following raw materials in parts by weight: 9 to 14 parts of alkyd resin, 4 to 6 parts of an antifoaming agent, 5 to 11 parts of wear-resistant auxiliary, 3 to 9 parts of organic bentonite, 6 to 14 parts of hydroxyethyl methacrylate, 2 to 8 parts of basic lead carbonate, 3 to 6 parts of montmorillonite, 4 to 8 parts of methyl benzoylformate, 3 to 5 parts of butyl acetate, 3 to 7 parts of precipitated silica, 5 to 10 parts of hydrogenated castor oil, 1 to 3 parts of ash calcium powder, 4 to 6 parts of lacquer wax and 4 to 7 parts of amine salt dispersant. The durable floor paint has the benefits of high wear resistance, certain strength and high brightness.

A vegetable oil polyol for flexible polyurethane foam, a preparation method and application thereof. The method includes the following steps: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; and (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain the vegetable oil polyol for flexible polyurethane foam.

The invention discloses a synthesis method for 2,3-diphenyl-1H-indene-1-one derivatives. The synthesis method comprises the steps of: adding benzoyl formic acid, a diphenyl acetylene compound, pentamethyl cyclopentadiene dichloride iridium, copper acetate, silver hexafluoroantimonate and a silver hexafluoroantimonate into an organic solvent; heating for reaction in the presence of air; and after the reaction, carrying out post-treatment to obtain the 2,3-diphenyl-1H-indene-1-one derivative. The method synthesizes the 2,3-diphenyl-1H-indene-1-one derivative in one step through simple and easilyavailable raw materials, so that the conversion efficiency is high and the atomic economical benefit is good. Meanwhile, the synthetic method is simple to operate, high in reaction yield and wide inprimer adaptability.

The invention relates to 7alpha-oxhydryl sterol dehydrogenase and an encoding gene and application thereof, and belongs to the technical field of biology. The 7alpha-oxhydryl sterol dehydrogenase is protein shown in SEQ ID NO.1 or protein with the same functions, obtained through substitution and/or deletion and/or addition of one or more amino acid residues of an amino acid sequence shown in theSEQ ID NO.1. The 7alpha-oxhydryl sterol dehydrogenase can catalyze an asymmetric reduction reaction of carbanyl groups of C7alpha-oxhydryl groups of taurocholic acid, glycocholic acid, taurochenodeoxycholic acid and glycochenodeoxycholic acid and catalyze an asymmetric reduction reaction of carbanyl groups and oxhydryl groups in benzoyl groups of ethyl benzoylformate. Compared with 7alpha-oxhydrylsterol dehydrogenase in clostridium sardiniense, the 7alpha-oxhydryl sterol dehydrogenase has higher catalytic activity and thermostability, and has very high industrial application value.

The invention discloses a method of synthesizing trifloxystrobin by using liquid phase polyglycol: (a) with the help of hydroxyl on the olyglycol to make condensation reation with o-methyl benzoylformic acid, loading the o-methyl benzoylformic acid on the olyglycol, so as to obtain 2-(2'-methylphenyl)-2- polyglycol carboxy acetate; (b) making the product obtained in step (a) react with methoxy amine and acid salts, obtaining 2-(2'-methylphenyl)-2- polyglycol carboxy acetate-O-methyl ketone oxime; (c) bromizing the product obtained in step (b) to obtain 2-(2'-bromomethylphenyl)-2- polyglycol carboxy acetate-O-methyl ketone oxime; (d) on basic condition, condensing the compound obtained in step (c) with meta-trifluoromethyl acetophenone oxime to obtain 2-[1'-{[(3'-trifluoromethylphenyl)-ethyl-imine]O}-O-tolyl]-2-polyglycol carboxy acetate-O- methyl ketone oxime; (e) making ester exchange reaction of the compound obtained in step (d) with methanol to obain the trifloxystrobin. On the basis of not changing properties of trifloxystrobin, it simplifies the step of separating and purifying in reacting course, reducing the cost.

The invention discloses a synthesis method of an acylated quinoline or isoquinoline derivative, belongs to the field of organic synthesis, and aims to solve the problems of complicated reaction, severe conditions and low environmental friendliness in the conventional acylated quinoline or isoquinoline derivative synthesis method. The synthesis method comprises the following steps: under a nitrogenatmosphere, adding quinoline or isoquinoline and benzoyl formic acid which are used as reaction raw materials, persulfate used as an oxidant and a metal iridium compound used as a visible light catalyst into a reaction container together with an organic solvent for reaction under a visible light illumination condition, and at the end of the reaction, filtering, concentrating, separating and purifying a reaction system, thus obtaining the acylated quinoline or isoquinoline derivative. According to the synthesis method, under the nitrogen atmosphere, the reaction system is placed under a visible light source for illumination to realize reaction, so that the whole reaction process is safe and environmentally friendly, reaction conditions are simple, and operation steps are convenient; the synthesis method belongs to an environment-friendly chemical process.