Culture medium for producing benzoylformic acid by fermentation method

A technology of acetophenone and culture medium, applied in the direction of fermentation, etc., can solve the problems of molecular shape influence, low biomass, substrate concentration and conversion rate can not continue to increase, and achieve the effect of convenient operation and high reaction specificity
CN101463369AInactive Publication Date: 2009-06-24SHANGHAI INST OF PHARMA IND CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND CO LTD
Publication Date
2009-06-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a culture medium for producing benzoylformic acid by fermentation method. The culture medium comprises calcium ion and D, L-phenylglycine and is characterized in that the initial pH value of the culture medium ranges from pH more than 7 to pH equal to 10. By adopting the culture medium to produce the benzoylformic acid, the substrate inventory rating can increase to 50g / L; the conversion rate can reach 36.8%, the response-specific is high, almost no byproduct exists, simple extraction is enough, and the operation is very convenient.
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Description

technical field

[0001] The invention belongs to the field of microbial fermentation engineering, in particular, the invention relates to a culture medium for producing acetophenone by fermentation. Background technique

[0002] Phenylglyoxilic acid, also known as benzoylformic acid, is an important intermediate in the synthesis of some pesticides and pharmaceutical products, and can be used to synthesize the herbicide fenmetrione and the pharmaceutical product Weichangning, etc. R(-)-mandelic acid is an extremely important chiral pharmaceutical intermediate, which is widely used in the asymmetric synthesis of optically pure amino acids, angiotensin converting enzyme inhibitors, and coenzyme A. At present, domestic studies have used acetophenone acid as a substrate to asymmetrically synthesize R(-)-mandelic acid. But the preparation method of acetophenone acid mainly contains two kinds of methods, benzoyl cyanide hydrolysis method and styrene oxidation method at present, the...

Claims

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