The invention discloses an S460ML extra-thick steel plate. Low carbon composition design is adopted, low Nb microalloying is added, an appropriate amount of Cr element improves the strength of steel,an appropriate amount of Ni element improves low-temperature impact toughness, the thermomechanical control process (TMCP) rolling technology with a low compression ratio of continuous casting blanksis adopted, rough rolling of a wide and thick plate mill under high pressure, two-stage ultralow temperature control rolling, ultrafast cooling after rolling and other technologies are utilized, the S460ML extra-thick steel plate is developed, the maximum thickness of the steel plate is 120mm, the performance is up to EN10025-4 standard requirements, and the low-temperature impact performance of the steel plate is excellent, especially the low-temperature impact energy at the temperature of -50 DEG C is equal to or higher than 100J. Because the carbon equivalent value (CEV) of the steel plateis equal to or less than 0.39%, the Pcm is equal to or less than 0.18%, the welding performance is more excellent, the economic and mass production of the steel plate can be realized, the use requirements of marine engineering and other complex working conditions and environments are met, and the comprehensive mechanical performance index reaches the same level of countries outside China.