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Chinese medicine composition for treating sepsis and preparation method thereof

A composition and technology for sepsis, applied in the field of traditional Chinese medicine composition and its preparation for preventing and treating sepsis, can solve the problems of ineffective curative effect, achieve anti-infection effect, important theoretical value and clinical value, and reduce the dosage Effect

Inactive Publication Date: 2011-10-12
无锡曙辉药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical application, it is found that the combination of prescribed Chinese and Western medicines has a certain curative effect on sepsis, but the curative effect is not obvious when used alone

Method used

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  • Chinese medicine composition for treating sepsis and preparation method thereof
  • Chinese medicine composition for treating sepsis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: Granules for the treatment of sepsis

[0068] 1. Composition (weight): Bupleurum 225g, Scutellaria baicalensis 225g, Salvia miltiorrhiza 225g, Rhubarb 45g, Coptidis 90g, Radix Paeoniae Rubra 150g, Ginseng 90g, Rehmannia 150g, Honeysuckle 225g, Fructus Aurantii 90g, Licorice 90g.

[0069] 2. Extraction method:

[0070] 1) Crush Bupleurum, honeysuckle, and Citrus aurantium into coarse powder, pass through a 10-mesh sieve, use 10 times the amount of water as a solvent, soak for 2 hours, heat and reflux, extract volatile oil, collect the extract and concentrate to a thick paste , vacuum: 0.09MPa; temperature: 60°C, standby;

[0071] 2) Scutellaria baicalensis, salvia miltiorrhiza, rhubarb, red peony, and ginseng were crushed into coarse powder, passed through a 10-mesh sieve, placed in a traditional Chinese medicine extraction unit, and 8 times the amount of 75% ethanol was added to reflux extraction for 3 times, each time for 2 hours, and filtered After pas...

Embodiment 2

[0076] Embodiment 2: acute toxicity test

[0077] The inventor carries out the preliminary observation of acute toxicity to the granule prepared in Example 1, considers that the occurrence chance of the acute toxicity of traditional Chinese medicine is very small, gives an acute toxicity test, with maximum concentration, maximum administration volume administration.

[0078] Medicine preparation: the dosage of the present invention is 12 grams of crude drug / bag, taken orally, three times a day. Calculated on the basis of adult body weight of 70 kg: 12 / 70=0.17 g / kg, converted to 0.2 kg rat oral equivalent measurement is: 12×0.018=0.216 (gram drug) / 200 (body weight gram) that is 1.08g / Kg.

[0079] Administration by intragastric administration: the maximum administration volume for each rat is 4ml. Dissolve the granules according to the maximum solubility: 1g / ml, and the dosage for each rat is 20g / Kg. The actual dosage of oral drug in rats is equivalent to 32g / kg in humans. Th...

Embodiment 3

[0082] Embodiment 3: be used for the oral liquid of treating sepsis

[0083]1. Composition (weight): Bupleurum 180g, Scutellaria baicalensis 180g, Salvia miltiorrhiza 180g, Rhubarb 36g, Coptidis 72g, Radix Paeoniae Rubra 120g, Ginseng 72g, Rehmannia 120g, Honeysuckle 180g, Citrus aurantium 72g, Licorice 72g.

[0084] 2. Preparation method:

[0085] 1) Crush Bupleurum, honeysuckle, and Citrus aurantium into coarse powder, pass through a 10-mesh sieve, use 10 times the amount of water as a solvent, soak for 2 hours, heat and reflux to extract volatile oil, collect the extract and concentrate to a thick paste, Vacuum degree: 0.09MPa; temperature: 60°C, standby;

[0086] 2) Scutellaria baicalensis, salvia miltiorrhiza, rhubarb, red peony, and ginseng are crushed into coarse powder, passed through a 10-40 mesh sieve, placed in a traditional Chinese medicine extraction unit, and 8 times the amount of 75% ethanol is added to reflux extraction for 3 times, each time for 2 hours , fi...

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Abstract

The invention relates to a Chinese medicine composition for treating sepsis and a preparation method thereof. The Chinese medicine composition comprises active ingredients prepared from the following traditional Chinese medicines in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of radix scutellariae, 10-20 parts of radix salviae miltiorrhizae, 1-5 parts of Chinese rhubarb, 5-10 parts of coptis chinensis, 8-10 parts of radix paeoniae rubra, 5-10 parts of ginseng, 8-10 parts of root of rehmannia, 10-20 parts of honeysuckle, 5-10 parts of fruit of trifoliate orange and 5-10 parts of liquorice. According to the Chinese medicine composition disclosed by the invention, fungi, toxicity and inflammation are treated simultaneously by utilizing synergistic effect of various ingredients, various ways and various target points of the traditional Chinese medicines; in addition, the Chinese medicine composition has unique and exact effects of controlling sepsis in early stage and turning and cutting off the disease development, and has excellent remote effects.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing and treating sepsis and a preparation method thereof. Background technique [0002] Sepsis is a systemic inflammatory response syndrome caused by infection. It is one of the serious complications of trauma, burn, shock, infection, ischemia, major surgery and other clinical critically ill patients, and it is also an important reason for inducing septic shock and multiple organ dysfunction syndrome (MODS). [0003] Sepsis is a complex syndrome of inflammatory dysregulation resulting from host failure to control infection, ultimately leading to irreversible damage to multiple organs. The inflammatory response of sepsis includes two distinct but inseparable processes, namely the systemic inflammatory response (SIRS) and the compensatory anti-inflammatory response (CARS). As a result, excessive SIRS and / or CARS can c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P31/00A61P29/00
Inventor 岳茂兴贾祥波陆继好
Owner 无锡曙辉药业有限公司
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