Liquid phase synthesis process of oxime strain ester by poly-ethandiol

A technology of polyethylene glycol ester and polyethylene glycol, applied in the field of preparation of organic compound pesticides, can solve problems such as synthesis without using tristrobin, and achieve the effect of simplifying the steps of separation and purification

Inactive Publication Date: 2005-01-05
TONGJI UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Liquid-phase synthesis on polyethylene glycol has been widely used for the synthesis of polypeptide nucleotides an

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liquid phase synthesis process of oxime strain ester by poly-ethandiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. Polyethylene glycol 2-(2'-methylphenyl)-2-carbonyl acetate

[0018] Add 2g (0.01mol) 2-(2,-methylphenyl)-2-carbonylacetic acid and 5ml thionyl dichloride into a 100ml round bottom flask equipped with a stirring and reflux condenser. Stir at room temperature for 5 hours, then rotate and evaporate. Add a small amount of thionyl chloride, add a small amount of dry n-heptane, rotate to evaporate the n-heptane, add 20ml of dichloromethane and 10g of polyethylene glycol to the flask, react at room temperature for 8 hours, distill the dichloromethane, add Diethyl ether, 2-(2'-methylphenyl)-2-carbonyl acetate polyethylene glycol ester is precipitated, dissolved in dichloromethane, dichloromethane is evaporated, and diethyl ether is added to obtain 9.8 g of relatively pure 2-( 2'-Methylphenyl)-2-carbonyl acetate polyethylene glycol ester.

[0019] 2. Synthesis of 2-(2'-methylphenyl)-2-carbonyl acetate polyethylene glycol ester-O-methyl ketoxime

[0020] Add 9.8g 2-(2'-methylpheny...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method of synthesizing trifloxystrobin by using liquid phase polyglycol: (a) with the help of hydroxyl on the olyglycol to make condensation reation with o-methyl benzoylformic acid, loading the o-methyl benzoylformic acid on the olyglycol, so as to obtain 2-(2'-methylphenyl)-2- polyglycol carboxy acetate; (b) making the product obtained in step (a) react with methoxy amine and acid salts, obtaining 2-(2'-methylphenyl)-2- polyglycol carboxy acetate-O-methyl ketone oxime; (c) bromizing the product obtained in step (b) to obtain 2-(2'-bromomethylphenyl)-2- polyglycol carboxy acetate-O-methyl ketone oxime; (d) on basic condition, condensing the compound obtained in step (c) with meta-trifluoromethyl acetophenone oxime to obtain 2-[1'-{[(3'-trifluoromethylphenyl)-ethyl-imine]O}-O-tolyl]-2-polyglycol carboxy acetate-O- methyl ketone oxime; (e) making ester exchange reaction of the compound obtained in step (d) with methanol to obain the trifloxystrobin. On the basis of not changing properties of trifloxystrobin, it simplifies the step of separating and purifying in reacting course, reducing the cost.

Description

Technical field [0001] The invention relates to a method for preparing organic compound pesticides, in particular to a liquid phase synthesis of trifloxystrobin ((E,E)-2-[1'-(3'-trifluoromethylbenzene) supported by polyethylene glycol Yl)-ethyl-imine-oxy-tolyl]-2-carbonyl acetate methyl-0-methanone oxime) synthesis method. Background technique [0002] Trifloxystrobin broad-spectrum fungicides are a new class of fluorine-containing fungicides successfully developed from the natural product Strobilurins as the leading compounds of fungicides. Its characteristics are: high-efficiency, broad-spectrum, protection, treatment, eradication, penetration, systemic activity, resistance to rain erosion, and long duration. It is effective against strains resistant to 1,4-demethylase inhibitors, benzamides, dicarboxamides and benzimidazoles, and has no cross-resistance to existing fungicides. It has good activity against almost all fungal diseases (ascomycetes, basidiomycetes, oomycetes and d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C249/12C07C251/48
Inventor 张荣华朱志良
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap