Process for preparing (R)-mandelic acid by microbial asymmetric reduction

A microbial method, asymmetric technology, applied in the field of asymmetric synthesis of chiral compounds by biological method, can solve the problems of many by-products, difficult separation of products and substrates, etc.
CN1840670AInactive Publication Date: 2006-10-04JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2006-10-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The asymmetrical reduction bio-method for (R)-mandelic acid comprises: screening the Saccharomyces cerevisiae AS 2.150 for culture and full cell preparation; with benzoylformic aicd as substrate, adding assist substrate, catalytic converting to obtain the product with optical purity up to 90%e.e. This invention improves product optical purity and yield, and has important meaning for enzyme development and resolution.
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Description

technical field

[0001] The invention discloses a method for preparing (R)-mandelic acid through asymmetric reduction of microorganisms, which belongs to the technical field of biological asymmetric synthesis of chiral compounds. Background technique

[0002] Racemic mandelic acid (also known as α-hydroxyphenylacetic acid, English name Mandelic acid), is composed of two enantiomers of (R)-mandelic acid and (S)-mandelic acid, of which (R)-mandelic acid It is an important chiral intermediate and is widely used in the synthesis of various drugs, such as antibiotics such as penicillins and cephalosporins, weight-loss drugs, anti-tumor drugs, drugs for treating depression and pesticides, etc.; and can As a chiral reagent, it is used to resolve other chiral compounds.

[0003] Chiral compounds play an important role in people's lives. Since the two enantiomers are different in pharmacology, toxicology and functional effects, the preparation of optically pure chiral modular compoun...

Claims

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