Combination product for prevention and/or treatment of cerebral ischemia and application thereof
A combination product, cerebral ischemia technology, applied in the field of biomedicine, can solve problems such as no research reports
Inactive Publication Date: 2018-07-24
KPC PHARM INC
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However, there is no research report on the application of artemisini
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Belonging to the technical field of biomedicine, the invention in particular relates to a combination product for prevention and/or treatment of cerebral ischemia and application thereof. The combination product is a pharmaceutical composition containing a Sur1 (sulfonylurea receptor 1) inhibitor and an artemisinin sesquiterpene lactone compound, or a combination of a first agent containing the Sur1 inhibitor and a second agent containing the artemisinin sesquiterpene lactone compound. According to the invention, the Sur1 inhibitor and the artemisinin sesquiterpene lactone compound form the combination product in an appropriate proportion form, have a synergistic effect, and can achieve a better therapeutic effect on cerebral ischemic disease than single use of the Sur1 inhibitor or the artemisinin sesquiterpene lactone compound.
Description
technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a combined product for preventing and / or treating cerebral ischemia and its application. Background technique [0002] Ischemic stroke has the characteristics of high morbidity, high mortality, high disability rate, high recurrence rate, and high medical expenses. It is a major chronic disease that endangers the health of Chinese residents. Clinical data statistics show that the global stroke mortality rate has surpassed cancer to become the disease with the highest single-disease mortality rate. It is well known that inflammatory response is an important part of the pathological injury process of cerebral ischemia, and it is also a potential factor that aggravates cerebral ischemic injury. In addition, ischemic stroke is often accompanied by cerebral edema and hemorrhagic transformation. Cerebral edema is the most serious complication of ischemic stroke. 80% of ...
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Login to view more IPC IPC(8): A61K45/06A61K31/357A61P9/10
CPCA61K31/357A61K45/06A61K2300/00
Inventor 任超王萍郑晓琼黄茜闫东明张建文杨兆祥
Owner KPC PHARM INC
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