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A kind of preparation method of self-temperature-controlling magnetic nanoparticles with high heat production

A technology of magnetic nanoparticles and self-temperature control, which is applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of high heat production rate, inability to self-control temperature, and inability to automatically control temperature, etc., to reduce potential side effects , improve security, and be easy to promote

Active Publication Date: 2020-04-07
DALIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] (2) The heat generation rate is high, but the temperature cannot be controlled by itself, and the field strength used also exceeds the clinical reference safety magnetic field, such as Jang J et al. (Jang J, Nah H, Lee J H, et al., Angewandte Chemie, 2009, Vo121, 1260) synthesized zinc-manganese ferrite has a high heat production rate of 432W / g, but it cannot self-control the temperature, and the frequency of the used field strength is 500kHz, which exceeds the frequency of the safe magnetic field for clinical application; Lee J H et al. (Lee J H , Jang J, Choi J, et al., Naturenanotechnology, 2011, Vo6, 418) The core-shell structure magnetic nanoparticles synthesized have a high heat production rate of 3886w / g, but cannot self-control the temperature, and the field of the magnetic field used The strength and frequency are 466Oe and 500kHz respectively, far exceeding the safe magnetic field for clinical application;
[0007] (3) The magnetic field used is a safe magnetic field for clinical application, and the heat production rate is relatively high, but it cannot self-control the temperature, such as Zhang L Y, etc. (zhang L Y, Gu HC, Wang X M, J.Magn.Magn.Mater., 2007, Vo311, 228) Synthetic dextran coated Fe 3 o 4 The heat production rate of the nano-particles in the clinical reference safe magnetic field (field strength 200Oe, frequency 100kHz) is relatively high, which is 75W / g, but it cannot automatically control the temperature;

Method used

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  • A kind of preparation method of self-temperature-controlling magnetic nanoparticles with high heat production
  • A kind of preparation method of self-temperature-controlling magnetic nanoparticles with high heat production
  • A kind of preparation method of self-temperature-controlling magnetic nanoparticles with high heat production

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Experimental program
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Effect test

Embodiment 1

[0033] (1) Preparation of precipitating agent: 30 g of NaOH was weighed and completely dissolved in 150 mL of deionized water, and a 5 mol / L NaOH aqueous solution was prepared as a precipitating agent.

[0034] (2) Preparation of metal salt ion solution: weigh 0.0096mol of ZnCl 2 , 0.00768 mol of CoCl 2 6H2O, 0.01152 mol of CrCl 3 ·6H 2 O and 0.024mol FeCl 3 ·6H 2 O was completely dissolved in 80mL of deionized water to prepare a precursor solution with a metal salt ion concentration of 0.66mol / L; ZnCl 2 、CoCl 2 ·6H 2 O, CrCl 3 ·6H 2 O and FeCl 3 ·6H 2 The molar ratio of O is 1.0:0.8:1.2:2.5.

[0035] (3) Preparation of precursor solution: under the condition of magnetic stirring, the NaOH aqueous solution prepared in step (1) was slowly added dropwise to the metal salt ion solution prepared in step (2), and the precursor solution was obtained after stirring for 30 minutes .

[0036] (4) Hydrothermal reaction to generate magnetic nanoparticles: transfer the precur...

Embodiment 2

[0042] (1) Preparation of precipitating agent: 18 g of NaOH was weighed and completely dissolved in 150 mL of deionized water, and a 3 mol / L NaOH aqueous solution was prepared as a precipitating agent.

[0043] (2) Preparation of metal salt ion solution: weigh 0.0048mol of ZnCl 2 , 0.00336 mol of CoCl 2 6H2O, 0.00432mol of CrCl 3 ·6H 2 O and 0.01152 mol of FeCl 3 ·6H 2 O was completely dissolved in 80mL of deionized water to prepare a precursor solution with a metal salt ion concentration of 0.3mol / L; ZnCl 2 、CoCl 2 ·6H 2 O, CrCl 3 ·6H 2 O and FeCl 3 ·6H 2 The molar ratio of O is 1.00:0.7:0.9:2.4.

[0044] (3) Preparation of precursor solution: under the condition of magnetic stirring, the NaOH aqueous solution prepared in step (1) was slowly added dropwise to the metal salt ion solution prepared in step (2), and the precursor solution was obtained after stirring for 30 minutes .

[0045] (4) Hydrothermal reaction to generate magnetic nanoparticles: transfer the p...

Embodiment 3

[0049] (1) Preparation of precipitating agent: 36 g of NaOH was weighed and completely dissolved in 150 mL of deionized water, and a 6 mol / L NaOH aqueous solution was prepared as a precipitating agent.

[0050] (2) Preparation of metal salt ion solution: weigh 0.012mol of ZnCl 2 , 0.012mol of CoCl 2 6H2O, 0.0156mol of CrCl 3 ·6H 2 O and 0.0324mol of FeCl 3 ·6H 2 O was completely dissolved in 80mL of deionized water to prepare a precursor solution with a metal salt ion concentration of 0.9mol / L; ZnCl 2 、CoCl 2 ·6H 2 O, CrCl 3 ·6H 2 O and FeCl 3 ·6H 2 The molar ratio of O is 1.0:1.0:1.3:2.7.

[0051] (3) Preparation of precursor solution: under the condition of magnetic stirring, the NaOH aqueous solution prepared in step (1) was slowly added dropwise to the metal salt ion solution prepared in step (2), and the precursor solution was obtained after stirring for 30 minutes .

[0052] (4) Hydrothermal reaction to generate magnetic nanoparticles: transfer the precursor...

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Abstract

The invention belongs to the technical field of magnetic inductive hyperthermia, and discloses a preparation method of high-heat-production automatic-temperature-control magnetic nanoparticles. The preparation method includes the steps: firstly, co-precipitating ZnCl2, CoCl2*6H2O, CrCl3*6H2O and FeCl3*6H2O metal salt ion solution and NaOH water solution to generate precursor solution; secondly, transferring the precursor solution into an autoclave and performing hydrothermal reaction for 2-24 hours at the temperature of 250-450 DEG C to generate the high-heat-production automatic-temperature-control magnetic nanoparticles. The preparation method is economical, simple and easy to popularize, the prepared magnetic nanoparticles are spinel structure ferrite which is stable in chemical property, low in Curie temperature and high in heat production rate, and safety of automatic-temperature-control magnetic inductive hyperthermia is improved.

Description

technical field [0001] The invention belongs to the technical field of magnetic induction hyperthermia for tumors, relates to the preparation of nanoparticles for magnetic induction hyperthermia, and particularly designs a method for preparing magnetic nanoparticles with high heat production and self-control temperature. Background technique [0002] Malignant tumor (commonly known as cancer) is a disease of uncontrolled growth of abnormal cells. Its morbidity and mortality are very high, and it is one of the biggest public health problems in the world. Currently, the main treatment methods for cancer are radiotherapy, chemotherapy and surgery. However, radiotherapy and chemotherapy are often accompanied by severe side effects, and surgical treatment is generally suitable for early-stage cancer patients, and surgical resection of tumor tissue will also remove part of the normal tissue, which is likely to cause certain sequelae and dysfunction after surgery. [0003] A large...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G51/00B82Y30/00A61K41/00A61P35/00
CPCA61K41/0052A61P35/00B82Y30/00C01G51/006C01P2002/32C01P2002/72C01P2004/04C01P2006/42
Inventor 张伟余小刚吴承伟
Owner DALIAN UNIV OF TECH
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