Composition with rhizoma alpiniae officinarum extract, flos chrysanthemi extract and uric acid reducing function and application of composition

A technology of galangal extract and chrysanthemum extract, which is applied in the deep processing of chrysanthemum and galangal, can solve the problems of damage to human health and many adverse reactions, and achieve the effect of easy-to-obtain raw materials and good flavor

Inactive Publication Date: 2018-08-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs for the clinical treatment of hyperuricemia are mainly western medicines. Although the curative effect is remarkable, there are many adverse reactions, which damage human health at the same time.

Method used

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  • Composition with rhizoma alpiniae officinarum extract, flos chrysanthemi extract and uric acid reducing function and application of composition
  • Composition with rhizoma alpiniae officinarum extract, flos chrysanthemi extract and uric acid reducing function and application of composition
  • Composition with rhizoma alpiniae officinarum extract, flos chrysanthemi extract and uric acid reducing function and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A composition with uric acid-lowering function containing galangal extract and chrysanthemum extract, which is composed of galangal extract and chrysanthemum extract in a mass ratio of 6:4, is recorded as composition 1, and specifically includes the following steps:

[0034] (1) Cross 60 mesh sieves after the dry galangal is pulverized, add the ethanol solution whose ethanol concentration is 60% (v / v) that the weight is 20 times of the dry galangal quality, stir at 200r / min rotating speed under room temperature for 4 hours, obtain the mixture Suspension A;

[0035] (2) Under the conditions of ultrasonic power of 600W and extraction temperature of 50°C, sonicate the suspension A for 1 hour, centrifuge at 3000g for 20min, and collect the supernatant;

[0036] (3) Add dry galangal powder of the same quality as in (1) to the supernatant, stir at a speed of 200 r / min at room temperature for 4 hours, and obtain a suspension B;

[0037] (4) Under the conditions of ultrasonic ...

Embodiment 2

[0047] A composition with uric acid-lowering function containing galangal extract and chrysanthemum extract, which is composed of galangal extract and mixed chrysanthemum extract in a mass ratio of 7:3, which is recorded as composition 2, and specifically includes the following steps :

[0048] (1) After the dried galangal is pulverized, cross a 60-mesh sieve, add an ethanol solution whose weight is 25 times that of the dry galangal with an ethanol concentration of 70% (v / v), and stir at 300 r / min for 5 hours at room temperature to obtain a mixture Suspension A;

[0049] (2) Under the conditions of ultrasonic power of 700W and extraction temperature of 55°C, sonicate the suspension A for 1.5 hours, centrifuge at 4000g for 25min, and collect the supernatant;

[0050] (3) Add dry galangal powder of the same quality as in (1) to the supernatant, and stir at a speed of 300 r / min at room temperature for 5 hours to obtain a suspension B;

[0051] (4) Under the conditions of ultras...

Embodiment 3

[0061] A composition with uric acid-lowering function containing galanga extract and chrysanthemum extract, which is composed of galanga extract and mixed chrysanthemum extract in a mass ratio of 8:2, which is recorded as composition 3.

[0062] The galangal extract used in compound composition 3 is obtained by ultrasonic extraction with ethanol combined with purification and enrichment of macroporous resin, which specifically includes the following steps:

[0063] (1) Cross 60 mesh sieves after the dry galangal is pulverized, add the ethanol solution whose ethanol concentration is 80% (v / v) that the weight is 30 times of dry galangal quality, stir at 400r / min rotating speed under the room temperature for 6 hours, obtain the mixture Suspension A;

[0064] (2) Under the condition of ultrasonic power of 800W and extraction temperature of 60°C, sonicate the suspension A for 2 hours, centrifuge at 5000g for 30min, and collect the supernatant;

[0065] (3) Add dry galangal powder ...

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Abstract

The invention discloses a composition with rhizoma alpiniae officinarum extract, flos chrysanthemi extract and a uric acid reducing function and application of the composition. The composition is a compound of the rhizoma alpiniae officinarum extract and the flos chrysanthemi extract. The rhizoma alpiniae officinarum extract is made of dry rhizoma alpiniae officinarum and is prepared by the aid ofultrasonic auxiliary ethanol extraction methods and macroporous resin separation and enrichment methods, and diphenylheptane and flavone compounds in the rhizoma alpiniae officinarum are pertinentlyextracted; the flos chrysanthemi extract is made of dry Bo flos chrysanthemi, Qi flos chrysanthemi and Jinsihuang flos chrysanthemi and is prepared by the aid of ethanol reflux extraction methods, andflavone substances in the flos chrysanthemi are pertinently extracted. The composition and the application have the advantages that the composition contains the abundant diphenylheptane compounds (more than 30%) and the abundant flavone (more than 7%) compounds, and is obvious in uric acid reducing activity (the in-vitro xanthine oxidase inhibitory activity is higher than 75 micro-mol of allopurinol equivalent weight / g); the composition has excellent flavor, is safe and reliable and can be applied to hyperuricemia prevention and adjuvant therapy healthcare foods or medicines, and raw materials for the composition are easily available.

Description

technical field [0001] The invention relates to the technical field of deep processing of galangal and chrysanthemum, in particular to a composition with uric acid-lowering function containing galangal extract and chrysanthemum extract and an application thereof. Background technique [0002] Hyperuricemia refers to the fasting blood uric acid level under a normal purine diet: men > 420 μmol / L, women > 360 μmol / L. With the improvement of people's living standards and changes in eating habits, the incidence of hyperuricemia and gout in my country has been increasing year by year in recent years. It is conservatively estimated that there are about 120 million patients with hyperuricemia in my country, accounting for about 10% of the total population of the country. Uric acid precipitates in the joints, soft tissues, cartilage and kidneys in the form of sodium salt, causing lesions in human organs and tissues, leading to the occurrence and development of gout. At the sam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P19/06A23L33/105
CPCA23V2002/00A61K36/287A61K36/9062A61K2236/333A61K2236/51A61K2236/53A61K2236/55A23L33/105A61P19/06A61K2300/00A23V2250/21A23V2200/30
Inventor 林恋竹彭岸赵谋明刘雪梅苏国万
Owner SOUTH CHINA UNIV OF TECH
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