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Preparation method of polyallylamine hydrochloride polymer

A technology of polyallylamine hydrochloride and polyallylamine hydrochloride, which is applied in the field of medicine, can solve the problems of non-cost-effectiveness, environmental protection, labor-intensive, etc., achieve good economic value and social value, and save organic solvents , The effect of simple preparation method

Inactive Publication Date: 2018-08-21
CHANGZHOU FANGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, it is very labor-intensive, not cost-effective and not environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of polyacrylamine hydrochloride polymer, comprising the following steps:

[0026] 1. React allylamine and hydrochloric acid solution with 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride to produce crude polyallylamine hydrochloride; propylene The mass ratio of amine and hydrochloric acid solution to 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride is 1:1.2:0.5:0.8. The specific steps are:

[0027] a. Add 40% HCl solution into the reactor, lower the temperature to below 3°C, mix allylamine and HCl solution, and stir and mix with a charge pump at a temperature of less than 20°C to obtain a mixture A;

[0028] b. At the same time, mix 3-chloropropylmethyldichlorosilane and its 60% ethanol solution with twice the mass, and stir and mix at 50°C with a charge pump to obtain mixture B;

[0029] c. Mixing mixture A and mixture B at a temperature of 25°C with charge pump stirring to obtain m...

Embodiment 2

[0034] A preparation method of polyacrylamine hydrochloride polymer, comprising the following steps:

[0035] 1. React allylamine and hydrochloric acid solution with 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride to produce crude polyallylamine hydrochloride; propylene The mass ratio of amine and hydrochloric acid solution to 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride is 1:1.2:0.5:0.8. The specific steps are:

[0036] a. Add 50% HCl solution into the reactor, lower the temperature to below 6°C, mix allylamine and HCl solution, and stir and mix with a charge pump at a temperature of less than 20°C to obtain a mixture A;

[0037] b. At the same time, mix 3-chloropropylmethyldichlorosilane and its 75% ethanol solution with 3 times the mass, and stir and mix with a charge pump at a temperature of 60° C. to obtain mixture B;

[0038] c. Mixing mixture A and mixture B at a temperature of 40°C with charge pump...

Embodiment 3

[0043] A preparation method of polyacrylamine hydrochloride polymer, comprising the following steps:

[0044] 1. React allylamine and hydrochloric acid solution with 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride to produce crude polyallylamine hydrochloride; propylene The mass ratio of amine and hydrochloric acid solution to 3-chloropropylmethyldichlorosilane and 2-2'-azodiisobutylamidine dihydrochloride is 1:1.2:0.5:0.8. The specific steps are:

[0045] a. Add 45% HCl solution into the reactor, lower the temperature to below 5°C, mix allylamine and HCl solution, and stir and mix with a charge pump at a temperature of less than 20°C to obtain a mixture A.

[0046] b. At the same time, mix 3-chloropropylmethyldichlorosilane with its 2.2 times mass 70% ethanol solution, and stir and mix at 55° C. with a charge pump to obtain mixture B.

[0047] c. Mixing mixture A and mixture B at a temperature of 30°C with charge pump stirring to obtain mix...

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Abstract

The invention discloses a preparation method of a polyallylamine hydrochloride polymer. The preparation method comprises the following steps: I, enabling acrylamine and a hydrochloric acid solution toreact with 3-chlorpropyl methyl dichlorosilane and 2-2'-diisobutyl amidine dihydrochloride to generate crude polyallylamine hydrochloride; II, concentrating the crude polyallylamine hydrochloride byusing a membrane filtration system and preparing into the polyacrylamide hydrochloride polymer with an average molecular weight of more than 1000 Daltons and less than 10000 Daltons, wherein the flowrate in the concentration step is 2-5 m<3>/hr. The preparation method of the polyacrylamide hydrochloride polymer, disclosed by the invention, has the benefits that the methanol precipitation separation step does not need to be repeated, and a large amount of organic solvents is saved; the preparation method is simple, and time and labor-saving, and has better economic values and social values.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of a polyacrylamine hydrochloride polymer. Background technique [0002] Polyacrylamine hydrochloride polymer is a cationic polymer electrolyte prepared by polymerization of acrylamine, which can be used to combine with anionic polymer electrolytes to form a layered structure of negative and positive electrohertz polymers. Absorbent film. Poly(allylamine) hydrochloride has many biochemical uses. [0003] Methods for producing polyacrylamine hydrochloride polymers are known techniques. US6,180,754, US6,362,266 and WO01 / 180721 disclose the preparation steps of a cross-linked polyacrylamine polymer. US 5,496,545 discloses a method for purifying poly(allylamine) hydrochloride (PAA-HCl) from a crude poly(allylamine) hydrochloride salt reaction mixture by precipitation using methanol solution. The solid PAA-HCl (precipitate) produced by the chemical reaction c...

Claims

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Application Information

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IPC IPC(8): C08F126/02C08F6/00
CPCC08F6/00C08F126/02
Inventor 陈宵鑫张寅徐乃林戴俊凌静
Owner CHANGZHOU FANGYUAN PHARMA
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