<19>F nuclear magnetic resonance probe, preparation method and applications thereof
A technology of nuclear magnetic resonance and probes, which can be used in peptide preparation methods, chemical instruments and methods, and pharmaceutical formulations, and can solve problems such as inability to reflect tumor-related conditions
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[0047] 19 Preparation of F NMR probes
[0048] 19 The preparation method of F nuclear magnetic resonance probe, such as Figure 1~6 shown, including the following steps:
[0049] 1) Synthesis of 2-cyano-6-aminobenzothiazole (CBT)
[0050] Under the condition of wt 98% concentrated sulfuric acid, 10 mmol 2-chlorobenzothiazole was reacted with 10 mmol potassium nitrate to generate 10 mmol 2-chloro-6-nitrobenzothiazole. Under the conditions of glacial acetic acid, water, ethanol, reduced iron powder, and activated carbon, the mixed solution of ethanol and water is the reaction solvent, and the dosage is 20 mL of ethanol, 20 mL of pure water, and the reduced iron powder and activated carbon are the catalysts of the reaction, and the dosage is iron Powder 0.01g, activated carbon 0.01g, 20mmol glacial acetic acid and 10mmol 2-chloro-6-nitrobenzothiazole were reacted to obtain 10mmol 2-chloro-6-aminobenzothiazole. Anhydrous N,N-dimethylformamide (DMF) is used as a reaction solve...
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