Compound maltodextrin as well as preparation method and application thereof

A technology of maltodextrin and cyclodextrin, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, non-effective ingredients of polymer compounds, etc., and can solve problems such as inability to granulate, mottle, and burnt black particles , to achieve the effects of excellent solubility and moisture absorption resistance, accelerated disintegration, and high molding rate

Active Publication Date: 2018-08-24
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the properties of unilateral granules such as rehmannia glutinosa, rehmannia glutinosa, angelica, and Chuanqiong, when dry-compressing granules using the above method, maltodextrin with a degree of hydrolysis expressed as 16-20 is added as an auxiliary material, and the obtained granules Burnt black or severe mottling, resulting in failure to granulate

Method used

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  • Compound maltodextrin as well as preparation method and application thereof
  • Compound maltodextrin as well as preparation method and application thereof
  • Compound maltodextrin as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1-5

[0029] Mix the maltodextrin with a degree of hydrolysis less than 11, maltodextrin with a degree of hydrolysis of 11-15 and microcrystalline cellulose according to the parts in Examples 1-5 in Table 1, and then add malt with a degree of hydrolysis of 16-20. Dextrin, mixed evenly again and adding lactose and β-cyclodextrin to obtain compound maltodextrin.

Embodiment 6

[0030] Example 6: Chinese medicine granules

[0031] The compound maltodextrin obtained in Example 1 is added to the traditional Chinese medicine extract powder after the extraction, concentration and drying of the traditional Chinese medicine, and dry granulation is carried out after mixing, wherein the traditional Chinese medicine extract powder is a pretreated traditional Chinese medicine extract powder, and the The treatment specifically includes the following steps: dissolving gelatin in distilled water, adding traditional Chinese medicine extract and stirring, keeping warm for use; dissolving Span 60 and Tween 60 in liquid paraffin, adding medicated gelatin, stirring and cooling to -3°C, Glutaraldehyde and isopropanol with a concentration of 2.3% are added, suction filtration after heat preservation, washing and drying, wherein the mass ratio of the gelatin to the traditional Chinese medicine extract is 1:1.

Embodiment 7

[0032] Example 7: Chinese medicine granules

[0033] The difference from Example 6 is that in Example 7, the compound maltodextrin prepared in Example 2 was added, and after adding the drug-containing gelatin, it was cooled to -3.5 ° C after stirring, and glutaraldehyde with a concentration of 2.35% and glutaraldehyde were added. The mass ratio of isopropyl alcohol, gelatin and Chinese herbal extract is 1:5.

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Abstract

The invention relates to compound maltodextrin as well as a preparation method and application thereof. The compound maltodextrin is suitable for single-component granules such as radix rehmanniae preparata, radix rehmanniae, Chinese angelica and rhizoma chuanxiong or a compound granule containing the medicines to perform dry pressing and pelleting, or is applied to solid beverage, and belongs tothe field of composite raw materials. The compound maltodextrin is prepared from the following components in parts by weight: 0 to 30 parts of maltodextrin of which hydrolysis degree is smaller than 11, 0 to 30 parts of maltodextrin of which the hydrolysis degree is 11 to 15, 0 to 30 parts of maltodextrin of which hydrolysis degree is 16 to 20, 0 to 15 parts of lactase, 0 to 5 parts of beta-cyclodextrin and 0 to 5 parts of microcrystalline cellulose. According to the preparation method of the compound maltodextrin, disclosed by the invention, by adopting the three kinds of maltodextrin with different hydrolysis degrees, the content of reducing sugar in the mixed maltodextrin can be reduced, and thereby the problem that due to browning reaction of amino acid in the radix rehmanniae preparata, the radix rehmanniae, the Chinese angelica and the rhizoma chuanxiong, the prepared granules are charred black or have severe spots and granulation forming cannot be achieved is solved.

Description

Field of Invention [0001] The present invention relates to a compound maltodextrin and a preparation method and application thereof, which are suitable for dry-pressed granules of unilateral granules such as Rehmannia glutinosa, raw rehmannia glutinosa, Angelica sinensis, Chuanqiong, etc. or compound granules containing these medicinal flavors, or used in solid beverages , belonging to the field of composite raw materials. Background technique [0002] Traditional Chinese medicine granules are the result of the reform of traditional Chinese medicine tablets. They are made from traditional Chinese medicine tablets by extraction, concentration, drying, granulation and other processes. They can be used for flexible formulation of clinical Chinese medicine prescriptions, and are a new innovation in clinical Chinese medicine. choose. [0003] At present, the granulation process of traditional Chinese medicine formula granules mainly adopts dry granulation. However, some varieti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/26A61K47/38A61K47/40A61K36/804A61K36/232A61K36/236A23L2/39A23L2/52
CPCA23L2/39A23L2/52A61K9/1623A61K9/1652A61K36/232A61K36/236A61K36/804
Inventor 周海滨江海龙陈旦凤陈斌徐旭峰
Owner NINGBO LIWAH PHARM CO LTD
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