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Novel medicine

A kind of technology of medicine and composition, applied in the field of treating kidney disease, especially renal insufficiency

Inactive Publication Date: 2018-08-24
成都创屹远景科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Novel medicine

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Embodiment 1

[0017] Embodiment 1: the preparation of tablet

[0018] Peiminin B 25g

[0019] Chelidonine 25g

[0020] Phenylalanine 5g

[0021] Take the above active ingredients, add appropriate amount of conventional excipients for tablet preparation, mix well, and make 1000 tablets with conventional tablet press machine.

Embodiment 2

[0022] Embodiment 2: the preparation of capsule

[0023] Peiminin B 40g

[0024] Chelidonine 10g

[0025] Phenylalanine 10g

[0026] Take the above active ingredients, add appropriate amount of conventional auxiliary materials for preparing capsules, mix evenly, and pack into capsules to make 1000 tablets.

Embodiment 3

[0027] Embodiment 3: Pharmacological experiment

[0028] 1. Establishment of a mouse model of acute kidney injury induced by cisplatin

[0029] Male Kunming KM mice, weighing 16-18 g, were randomly divided into solvent control group, cisplatin model group and drug administration group according to body weight, totally 6 groups, 8 mice in each group. The control group was intraperitoneally injected with normal saline. Cisplatin was dissolved in normal saline and injected intraperitoneally at 7 mg / kg to prepare an acute kidney injury model. The medicine of the embodiment of the present invention began to be administered orally 2 days before the injection of cisplatin, once a day, and administered five times in total; the positive control drug Benazepril (K) was orally administered at the same time when injecting cisplatin, once a day, administered altogether Three times, the dosage of each of the above is 0.4mg / 20g body weight. On the 3rd, 5th, and 7th day after the injection...

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Abstract

The invention relates to a novel medicine. The novel medicine comprises peiminine, chelidonine and phenylalanine. The invention also relates to application of the novel medicine in treatment of nephrosis, especially renal insufficiency.

Description

technical field [0001] The present invention relates to a kind of new medicine, comprises peiminine B, chelidonine and phenylalanine. The invention also relates to the application of the medicine in treating kidney disease, especially renal insufficiency. Background technique [0002] Peiminine, CAS No. 18059-10-4. [0003] Chelidonine is extracted from celandine, a plant of the family Papaveraceae. .For gastrointestinal colic, gastric and duodenal ulcers, renal colic, dysmenorrhea and biliary ascariasis pain relief. It can be used in female sterilization surgery with the use of local anesthetics. Compound chelidonine has good analgesic effect and can be used for rheumatoid arthritis, trauma and cancer pain. Commercially available compound chelidonine injection: each ml contains 0.6 mg of chelidonine, 3 mg of Fangji all-alkali, 2.4 mg of Corydalis all-alkali, etc. [0004] Phenylalanine is one of the essential amino acids for the human body. It is a white crystal or cry...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61K31/365A61K31/198A61K31/58A61P13/12
CPCA61K31/4741A61K31/198A61K31/365A61K31/58A61P13/12A61K2300/00
Inventor 刘颖
Owner 成都创屹远景科技有限公司
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