Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate

A technology of methyl butyrate and nutrition, which is applied in the direction of drug combination, drug delivery, active ingredients of anhydride/acid/halide, etc. It can solve the problems of HMB difficult to handle, reduce manufacturing efficiency, and difficult to prepare the composition

Inactive Publication Date: 2018-09-04
ABBOTT LAB INC
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, HMB is expensive and compositions containing HMB are difficult to prepare
This is because HMB is difficult to handle and requires many special provisions that reduce manufacturing efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate
  • Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate
  • Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0062]According to exemplary embodiments, multiple proteins, including one protein or more than one protein, can be used to provide a source of protein in a nutritional combination. Proteins suitable for use in nutritional compositions according to embodiments disclosed herein include, but are not limited to, hydrolyzed, partially hydrolyzed or non-hydrolyzed proteins or protein sources, and may be derived from any known or otherwise suitable source, such as milk (eg, milk). , casein, whey), animals (eg, meat, fish), grains (eg, rice, corn), vegetables (eg, soybeans, peas, potatoes), or combinations thereof.

[0063] Non-limiting examples of such protein sources include whey protein concentrate, whey protein isolate, whey protein hydrolyzate, acid casein, sodium caseinate, calcium caseinate, potassium caseinate, casein hydrolysate milk protein concentrate, milk protein isolate, milk protein hydrolyzate, skim milk, low-fat milk, nonfat dry milk, skim milk powder, skim milk conc...

Embodiment 1

[0148] A study was conducted to investigate the effect of a composition containing HMB and white curcumin (THC) in a well-validated animal model of human muscle loss (β-Hydroxy-β-methylbutyrate (HMB) normalizes dexamethasone-induced autophagy-lysosomal pathway in skeletal muscle. Giron MD, Vilchez JD, Shreeram S, Salto R, Manzano M, Cabrera E, Campos N, Edens NK, RuedaR, Lopez-Pedrosa JM. PLoS One. 2015 Feb 6;10(2):e0117520 .doi:10.1371 / journal.pone.0117520.eCollection2015).

[0149] Experimental Design - Male Sprague-Dawley rats (8-10 weeks old) (n=42) weighing 270-310 g were randomly assigned to seven experimental groups (six rats per group). Groups 1-6 were administered dexamethasone (a synthetic glucocorticoid) at 0.1 mg / kg / day by intraperitoneal injection for 21 days to induce muscle loss. The dexamethasone was administered at 2 mL / kg of 1.75 mg dexamethasone / 35 mL normal saline. Group 7 (sham control) was administered saline without dexamethasone.

[0150] Group 1 (pa...

Embodiment 2

[0162] Example 2 illustrates a nutritional powder according to the present disclosure, the ingredients of which are listed in the table below. The product is prepared by spray drying method. All ingredients are listed in kg / 1000kg bulk product unless otherwise specified. Comparison with known HMB-containing nutritional powders.

[0163]

[0164]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to a pharmaceutical or nutritional combination comprising beta-hydroxy beta-methylbutyrate (HMB) and tetrahydrocurcumin (THC) and methods comprising administering the combination to a subject. The methods of the invention relate to attenuating muscle protein degradation and / or preserving lean body mass in the subject.

Description

technical field [0001] The present invention relates to a combination comprising β-hydroxy β-methylbutyrate (HMB) and tetrahydrocurcumin (THC). The combination has been found to be particularly useful in reducing muscle protein degradation, maintaining lean body mass, or both, in a subject in need thereof. Background technique [0002] Loss of lean body mass occurs with aging, muscle disuse, surgery, and many catabolic conditions, including but not limited to cancer, burns, chronic obstructive pulmonary disease, congestive heart failure, and chronic kidney disease. This loss of lean body mass results in decreased function, loss of independence and increased disease burden. Loss of lean body mass is often attributed to an imbalance in the rate of muscle protein degradation over the rate of muscle protein synthesis. [0003] One compound that has been shown to reduce muscle protein degradation and maintain lean body mass is beta-hydroxybeta-methylbutyrate (HMB), a metabolite...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/19A61P3/04
CPCA61K31/12A61K31/19A61P3/04A61P21/00A61P43/00A61K2300/00A23L2/38A61K9/0053A61K9/0095A23L33/30
Inventor S·萨思亚瓦吉斯瓦兰
Owner ABBOTT LAB INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap