A kind of modified hydroxyapatite composite polycaprolactone-chitosan bilayer film and preparation method thereof

A technology of hydroxyapatite and polycaprolactone, applied in the direction of prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor biocompatibility of bone cells, unable to promote the growth of bone cells and soft tissue cells at the same time, etc. achieve the effect of promoting growth

Inactive Publication Date: 2021-04-06
HAINAN VOCATIONAL COLLEGE OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these guiding bone regeneration membranes can separate soft tissue cells from bone defects, the biocompatibility of the guiding bone regeneration membranes in the prior art with soft tissue cells and bone cells is not good, resulting in the guiding bone regeneration in the prior art. Sexual bone regeneration membrane cannot promote the growth of bone cells and soft tissue cells at the same time

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  • A kind of modified hydroxyapatite composite polycaprolactone-chitosan bilayer film and preparation method thereof
  • A kind of modified hydroxyapatite composite polycaprolactone-chitosan bilayer film and preparation method thereof
  • A kind of modified hydroxyapatite composite polycaprolactone-chitosan bilayer film and preparation method thereof

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preparation example Construction

[0044] In the present invention, the modified hydroxyapatite is obtained by modifying hydroxyapatite with a silane coupling agent; the preparation method of the modified hydroxyapatite preferably includes the following steps: combining the silane coupling agent and hydroxyl The apatite is mixed in an alcoholic organic solvent, and then the obtained dispersion is subjected to ultrasonication, filtration, washing, centrifugation, drying and grinding in sequence.

[0045] In the present invention, the volume ratio of the silane coupling agent to the mass ratio of hydroxyapatite is preferably 1 mL:0.5-2.5 g, more preferably 1 mL:1.0-2.0 g. In the present invention, the silane coupling agent is preferably γ-methacryloxypropyltrimethoxysilane.

[0046] In the present invention, the volume ratio of the alcohol organic solvent to hydroxyapatite is preferably 20-30mL:10g, more preferably 22-28mL:10g, and more preferably 24-26mL:10g. In the present invention, the alcoholic organic solv...

Embodiment 1

[0085] Take 50 mL of 0.05 mol / mL calcium nitrate solution and 50 mL of 0.3 mol / mL diammonium hydrogen phosphate solution. The pH of the two was adjusted to 11 with ammonia water respectively, and the diammonium hydrogen phosphate solution was mixed with 1.0ml·min -1 Add dropwise to the calcium nitrate solution at a high speed, stir while adding dropwise, and stir the solution at 85°C for 12h after the reaction. At 25°C, sink for 12h. After centrifugation, it was repeatedly washed with water three times, and dried in vacuum at 80° C. for 24 hours to obtain hydroxyapatite.

[0086] Disperse 4mL of silane coupling agent in 26mL of ethanol; disperse 10g of hydroxyapatite in 60mL of ethanol; after sonicating for 10min, mix the above two solutions, and then sonicate for 40min. Filtration after sonication yielded a mixture. The mixture was washed with ethanol, centrifuged, dried at 80°C for 2 hours, then vacuum-dried at 100°C for 24 hours, ground to obtain a sample, and passed thr...

Embodiment 2

[0090] Take 50 mL of 0.1 mol / mL calcium nitrate solution and 50 mL of 0.3 mol / mL diammonium hydrogen phosphate solution. The pH of the two was adjusted to 11 with ammonia water respectively, and the diammonium hydrogen phosphate solution was mixed with 1.2ml·min -1 Add dropwise to the calcium nitrate solution at a high speed, stir while adding dropwise, and stir the solution at 85°C for 12h after the reaction. At 25°C, sink for 12h. After centrifugation, it was repeatedly washed with water three times, dried in vacuum at 80°C for 24 hours, and hydroxyapatite was obtained.

[0091] Disperse 4mL of silane coupling agent in 25mL of ethanol; disperse 10g of hydroxyapatite in 55mL of ethanol; after sonicating for 10min, mix the above two solutions, and then sonicate for 40min. Filtration after sonication yielded a mixture. The mixture was washed with ethanol, centrifuged, dried at 80°C for 2 hours, then vacuum-dried at 100°C for 24 hours, ground to obtain a sample, and passed th...

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Abstract

The invention provides a modified hydroxyapatite composite polycaprolactone-chitosan double-layer film, comprising a laminated modified hydroxyapatite composite polycaprolactone film and a chitosan film; the modified The hydroxyapatite composite polycaprolactone film comprises a polycaprolactone film and modified hydroxyapatite dispersed in the polycaprolactone film; the modified hydroxyapatite is composed of hydroxyapatite via silane Modified by coupling agent. The modified hydroxyapatite composite polycaprolactone-chitosan double-layer membrane provided by the present invention can be used as a guiding bone regeneration membrane and applied to bone defect areas, and the modified hydroxyapatite composite polycaprolactone in the double-layer membrane One side of the ester film is attached to the bone defect area, which can promote the growth of bone cells; the side of the chitosan film in the double-layer film is attached to the soft tissue area, which can promote the growth of soft tissue cells.

Description

technical field [0001] The invention relates to the technical field of double-layer membranes, in particular to a modified hydroxyapatite composite polycaprolactone-chitosan double-layer membrane and a preparation method thereof. Background technique [0002] When a bone defect occurs, the faster-growing soft tissue cells will grow into the defect area earlier than the osteoblasts, affecting the growth of bone cells, thereby affecting the bone repair effect. In order to solve this problem, a guided bone regeneration membrane is usually used to separate the soft tissue cells from the bone defect area, preventing the soft tissue cells from growing too fast into the bone defect area and affecting the growth of bone cells. degradation. [0003] The biocompatibility of guided bone regeneration membrane with soft tissue cells and bone cells directly affects the growth of soft tissue cells and bone cells. Currently, guided bone regeneration membranes usually include nanofiber mem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/50
CPCA61L27/20A61L27/46A61L27/50A61L2430/02C08L67/04C08L5/08
Inventor 李桂娟王恩辉罗海希夏伟徐雪峰
Owner HAINAN VOCATIONAL COLLEGE OF SCI & TECH
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