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A technology of oral care and health care liquid, which is applied in oral care, medical science, dentistry, etc., can solve problems such as strong discomfort, achieve the effects of improving bitterness, increasing serum zinc concentration, and strengthening bactericidal and antibacterial effects
Inactive Publication Date: 2018-10-16
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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In addition, many studies have also shown that zinc deficiency is one of the most important pathogenic factors of recurrent aphthous ulcers. Therefore, adding zinc salts to oral care products is beneficial to the treatment of recurrent aphthous ulcers. However, zinc salts have a very strong metallic, bitter and astringent taste. , especially when oral care products contain high doses of zinc salts
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Embodiment 1
[0022] The impact of embodiment 1 zinc citrate on the antibacterial effect of lysozyme
[0023] 1. Prepare compositions containing zinc citrate and lysozyme in different proportions, see formulas 1-7 in Table 1 for specific formulas.
[0024] 2. Referring to QB 2738-2012 Evaluation Method of Antibacterial and Antibacterial Effects of Daily Chemical Products, determine the inhibition of Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, and Escherichia coli of the compositions of formulas 1 to 7 in Table 1 effect.
[0025] 3. Experimental results
[0026] According to the ratio of formulas 1-7, a composition containing lysozyme is prepared, and the antibacterial rate (%) of the composition is tested immediately after the composition is obtained.
[0027] Antibacterial effect of table 1 formula 1~7
[0028]
[0029]
[0030] In addition, the bacteriostatic rate (%) when adding lysozyme and zinc citrate was also measured, as shown in Table 2.
[0031...
Embodiment 2
[0039] Embodiment 2 A kind of oral care health care liquid containing lysozyme
[0040] 1. An oral care liquid containing lysozyme, the specific formula is shown in Application Examples 1-4 in Table 4.
[0041]2. Referring to QB 2738-2012 Evaluation method of antibacterial and antibacterial effects of daily chemical products, the inhibitory effects of the oral care and health care solutions of each application example on Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, and Escherichia coli were determined. After placing the oral care and health care solutions of Application Examples 1 to 4 at a high temperature of 45°C for 3 months, the antibacterial test was carried out. And synchronously test the bacteriostatic effect of contrast 1, contrast 2 and contrast 3 (contrast 1 except not containing sodium chloride, the kind and content of all the other components are identical with application example 1; Contrast 2 except not containing humectant, all the othe...
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Abstract
The invention discloses oral-care health-care liquid containing lysozyme. The oral-care health-care liquid is prepared from the following components in percentage by mass: 1 to 20 percent of humectant, 0.01 to 1 percent of sodium chloride, 0.1 to 2 percent of emulsifier, 0.01 to 1 percent of chelating agent, 0.01 to 2 percent of the lysozyme, 0.01 to 0.1 percent of zinc-containing compound, 0.01 to 1 percent of essence, 0.01 to 0.5 percent of sweetener and the balance of de-ionized water. According to the oral-care health-care liquid disclosed by the invention, the zinc-containing compound andthe lysozyme are compounded; on one hand, the concentration of serum zinc of a local part of an oral cavity can be improved, and zinc ions are used for reducing bacterial colonization in the oral cavity through inhibiting the glucose metabolism of bacteria and a mutual effect between cell walls of the bacteria; the sterilization and bacterium-inhibition effect of the lysozyme also can be reinforced in the presence of the zinc ions; on the other hand, the zinc-containing compound and the lysozyme are combined to use so that a metal taste and a bitter taste, caused by zinc salt, can be coveredand reduced very well. Furthermore, sodium chloride, the humectant and other components are added and are compounded, so that the bitter taste of the lysozyme can be improved and the sterilization activity of the lysozyme also can be effectively improved, and furthermore, the aim of efficiently and persistently inhibiting bacteria is realized.
Description
technical field [0001] The invention relates to the technical field of lysozyme application, in particular to an oral care and health care solution containing lysozyme. Background technique [0002] Oral problems are mainly caused by bacteria. Using effective mouthwash, toothpaste and treatment of oral diseases can significantly reduce the number of pathogenic bacteria in the oral cavity, improve or even eliminate oral diseases. Oral care products such as mouthwash and toothpaste can achieve these functions mainly by the active ingredients or antibacterial ingredients in the products. These antibacterial ingredients are mostly Chinese herbal medicines and chemical antibacterial agents. Chemical antibacterial agents such as triclosan , cetylpyridinium chloride, chlorhexidine, antibiotics, etc. Frequent use of oral care products containing these ingredients is likely to cause oral bacterial ecological imbalance, or cause bacteria to develop drug resistance, which cannot preven...
Claims
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