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Compositions for the treatment of joints

A composition and joint technology, applied in drug combination, drug delivery, tissue regeneration, etc.

Pending Publication Date: 2018-10-23
CORMEDIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no proven treatments to slow or reverse osteoarthritis

Method used

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  • Compositions for the treatment of joints
  • Compositions for the treatment of joints
  • Compositions for the treatment of joints

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0133] The following evaluations were performed to evaluate the performance of gels comprising hyaluronic acid and taurolidine. Solution exposure of hyaluronic acid / taurolidine hydrogel submerged in earlier concentrations of the 2 test microorganisms was performed. Additionally, the physical properties of the hydrogels were evaluated to determine their shear / thixotropic properties.

[0134] Hyaluronic Acid Hydrogel Preparation

[0135]A formulation of taurolidine in an aqueous solution of hyaluronic acid cross-linked with 1,4-butanediol diglycidyl ether (BDDE) was prepared. 3 concentrations (1.5%, 3% and 6%) of taurolidine were formulated in aqueous solutions of 3 molecular weights of cross-linked hyaluronic acid: low molecular weight (LMW) 21-40 kDa, medium molecular weight (MMW) 310-450 kDa and high molecular weight (HMW) 750kDa-1.0 MDa. A control formulation without the addition of taurolidine was prepared. The composition of each formulation is given in Table 1 below. ...

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Abstract

A composition for treating a joint condition, the composition comprising: hyaluronic acid; and taurolidine.

Description

[0001] applicant [0002] CorMedix Inc. [0003] inventor [0004] Robert DiLuccio [0005] Bruce Reidenberg [0006] Randy Milby [0007] References to Pending Prior Patent Applications [0008] This patent application: [0009] (i) CLAIMING THE SERIAL NUMBER OF THE PENDING PRECEDING U.S. PROVISIONAL PATENT APPLICATION, filed 31 August 2015 by CorMedix Inc. and Robert DiLuccio et al., entitled ANTIMICROBIAL COMPOSITIONS FOR TREATMENT OF JOINTS 62 / 211,922 (Attorney Docket No. CORMEDIX-8 PROV); and [0010] (ii) Claiming the Pending Prior U.S. Provisional Patent Application Series filed August 31, 2015 by CorMedix Inc. and Robert DiLuccio et al., entitled INTRA-ARTICULAR FORMULATION OF TAUROLIDINE Interest of No. 62 / 211,904 (Attorney's Case No. CORMEDIX-12 PROV). [0011] Both (2) of the patent applications identified above are hereby incorporated by reference. field of invention [0012] The present invention relates generally to compositions and methods for treating ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/728A61P19/02
CPCA61K9/0024A61K47/36A61K9/5123A61K9/5169A61L2300/404A61L2400/12A61K2300/00A61P19/02A61L27/54A61K31/728A61K31/549A61K38/1875A61K9/0019A61K9/06A61L27/52A61L27/20A61L2430/24A61L2400/06C08L5/08
Inventor R.迪卢西奥B.雷登伯格R.米尔比
Owner CORMEDIX