Masticinic acid-myrrh terpene compatible composition as well as preparation method and application thereof

A boswellic acid and composition technology, applied in the preparation and application of natural composition analgesics, can solve problems such as adverse effects and ineffectiveness of patients

Inactive Publication Date: 2018-11-13
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have negative characteristics such as addiction, tolerance, or adverse effects on the gastrointestinal system, vascular system, blood coagulation system, liver and kidney, or are ineffective for some patients.

Method used

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  • Masticinic acid-myrrh terpene compatible composition as well as preparation method and application thereof
  • Masticinic acid-myrrh terpene compatible composition as well as preparation method and application thereof
  • Masticinic acid-myrrh terpene compatible composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of Boswellic Acid and Bisabolterpene Compatibility Composition

[0024] a: Extraction and preparation of boswellic acid and bisabolene

[0025] Weigh 50g each of frankincense and myrrh, crush them into coarse powder, and extract 2 times with 95% ethanol with 10 times the weight of the medicinal materials, 2 hours each time, combine the filtrates, concentrate, and obtain 27.8g of boswellic acid crude extract, myrrh Terpene crude extract 24.9g.

[0026] b: Purification and preparation of boswellic acid and myrrh sesquiterpene

[0027] Extract the crude boswellic acid extract and the crude sesquiterpene myrrh extract with ethyl acetate, repeat three times, combine the extracts from the ethyl acetate fractions, and concentrate under reduced pressure to obtain a concentrated solution of the ethyl acetate fractions. The ethyl acetate part of frankincense and the ethyl acetate part of myrrh were sampled by dry mixing, separated and eluted through a sil...

Embodiment 2

[0029] Embodiment 2: Preparation of boswellic acid and bisabolterpene compatibility composition

[0030] a: Extraction and preparation of boswellic acid and bisabolene

[0031] Weighed 50g each of frankincense and myrrh, crushed them into coarse powder, refluxed and extracted twice with 60% ethanol with 10 times the weight of the medicinal materials, 2 hours each time, combined the filtrates, concentrated, and obtained 28.5g of boswellic acid crude extract, myrrh Terpene crude extract 23.4g.

[0032] b: Purification and preparation of boswellic acid and myrrh sesquiterpene

[0033]Extract the crude boswellic acid extract and the crude sesquiterpene myrrh extract with ethyl acetate, repeat three times, combine the extracts from the ethyl acetate fractions, and concentrate under reduced pressure to obtain a concentrated solution of the ethyl acetate fractions. The ethyl acetate part of frankincense and the ethyl acetate part of myrrh were sampled by dry mixing, separated and e...

Embodiment 3

[0035] Embodiment 3: Preparation of boswellic acid and bisabolene compatibility composition

[0036] a: Extraction and preparation of boswellic acid and bisabolene

[0037] Weigh 50g each of frankincense and myrrh, grind them into coarse powder, and extract 2 times with 10 times the weight of 75% ethanol under reflux, each time for 2 hours, combine the filtrates, concentrate, and obtain 29.1g of boswellic acid crude extract, myrrh Terpene crude extract 25.3g.

[0038] b: Purification and preparation of boswellic acid and myrrh sesquiterpene

[0039] Extract the crude boswellic acid extract and the crude sesquiterpene myrrh extract with ethyl acetate, repeat three times, combine the extracts from the ethyl acetate fractions, and concentrate under reduced pressure to obtain a concentrated solution of the ethyl acetate fractions. The ethyl acetate part of frankincense and the ethyl acetate part of myrrh were sampled by dry mixing, separated and eluted through a silica gel colum...

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Abstract

The invention relates to a masticinic acid-myrrh terpene compatible composition. Masticinic acid and myrrh terpene taken as basic active components are compatible to form a pharmaceutical compositionwith remarkable anti-inflammatory and pain-easing effects, the pharmaceutical composition has the effects superior to the independent use effects of masticinic acid and myrrh terpene. The invention further discloses a preparation method of the pharmaceutical composition and relates to application of the pharmaceutical composition in the treatment of chronic pain diseases such as inflammatory pain,cancer pain, neuropathic pain and the like. The pharmaceutical composition is used as an analgesic, simultaneously has the anti-inflammatory and anti-tumor effects and further has the advantages thatthe composition has no dependency after being used for a long time, and the withdrawal reaction is avoided.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of a natural composition analgesic, and specifically relates to a composition composed of boswellic acid and bisabolterpene, and its application and application in the preparation of prevention or treatment of chronic pain diseases or health care products Preparation. Background technique [0002] Chronic pain is defined as pain that lasts for more than 3 months, with a frequency of at least once a week, associated with unpleasant sensations and emotions, and may be associated with existing or potential tissue damage. Chronic pain is a common type of pain, the most common clinical disease, and one of the diseases that seriously affect human health. Epidemiological studies have shown that the proportion of the population suffering from chronic pain is as high as about 20% to 30%. Studies have shown that a part of chronic pain develops from acute trauma, such as chronic postope...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/328A61K36/324A61K31/56A61P29/00A61P35/00
CPCA61K31/56A61K36/324A61K36/328A61K2236/333A61K2236/39A61K2236/55A61P29/00A61P35/00A61K2300/00
Inventor宿树兰段金廒钱大玮于光
OwnerNANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE