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Caries-preventing toothpaste and preparation method thereof

A technology for toothpaste and anti-caries, applied in the field of skin care, can solve problems such as studies that have not been reported yet

Active Publication Date: 2018-11-23
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Benzyl isothiocyanate has made great progress in anti-cancer and anti-cancer research, and has strong biological activity, but the research on inhibiting the growth of oral bacteria has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] First, put 39.3% deionized water into the reaction kettle, turn on the mixer, set the stirring speed to 50rpm, add 35% sodium bicarbonate and 18% sorbitol successively, after all dissolve, increase the stirring speed to 80rpm , then add 0.60% glycerin, 0.50% sodium carboxymethyl cellulose, 0.14% sodium alginate and 0.10% methyl p-hydroxybenzoate into the reaction kettle, keep stirring for 30 minutes, and carry out pre-mixing and dispersion treatment;

[0025] Then, turn on the heating device, set the temperature at 70°C, slowly add 0.004% papaya seed volatile oil, 0.846% chitosan, and 3.50% sodium hyaluronate to the reaction kettle, and continue to stir for 1h after adding, and then Keep warm for 30 minutes to ensure even mixing;

[0026] Finally, reduce the stirring speed to 30rpm, add 0.01% xylitol, 2.00% sodium lauryl sulfate, continue to stir for 1h, turn off the heating device and stirring device, slowly drop to room temperature, let it stand for 1h, and discharge ...

Embodiment 2

[0029] First, put 33.55% deionized water into the reaction kettle, turn on the mixer, set the stirring speed to 50rpm, add 38% sodium bicarbonate and 19% sorbitol successively, after all dissolve, increase the stirring speed to 80rpm , then add 0.80% glycerin, 0.60% sodium carboxymethyl cellulose, 0.16% sodium alginate and 0.20% methyl p-hydroxybenzoate into the reaction kettle in turn, keep stirring for 30 minutes, and carry out pre-mixing and dispersion treatment;

[0030] Then, turn on the heating device, set the temperature at 78°C, slowly add 0.006% papaya seed volatile oil, 0.864% chitosan, and 3.80% sodium hyaluronate to the reaction kettle, and continue to stir for 1h after adding, and then Keep warm for 30 minutes to ensure even mixing;

[0031] Finally, reduce the stirring speed to 30rpm, add 0.02% xylitol and 3.00% sodium lauryl sulfate, continue to stir for 1h, turn off the heating device and stirring device, slowly lower to room temperature, let stand for 1h, and ...

Embodiment 3

[0034] First, put 31.04% deionized water into the reaction kettle, turn on the mixer, set the stirring speed to 50rpm, add 40% sodium bicarbonate and 18% sorbitol successively, after all dissolve, increase the stirring speed to 80rpm , then sequentially add 1.00% glycerin, 0.70% sodium carboxymethylcellulose, 0.18% sodium alginate and 0.10% methyl p-hydroxybenzoate into the reaction kettle, keep stirring for 30 minutes, and carry out pre-mixing and dispersion treatment;

[0035] Then, turn on the heating device, set the temperature at 75°C, slowly add 0.007% papaya seed volatile oil, 0.963% chitosan, and 4.00% sodium hyaluronate to the reaction kettle, and continue to stir for 1h after adding, and then Keep warm for 30 minutes to ensure even mixing;

[0036] Finally, reduce the stirring speed to 30rpm, add 0.01% xylitol and 4.00% sodium lauryl sulfate, continue stirring for 1h, turn off the heating device and stirring device, slowly lower to room temperature, let stand for 1h,...

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Abstract

The invention relates to caries-preventing toothpaste and a preparation method thereof, and belongs to the technical field of toothpaste. The caries-preventing toothpaste has the beneficial effects that papaya-seed volatile oil and chitosan are both added to match mutually, the synergistic effect of preventing caries by mutual promotion is achieved, meanwhile not only is the problem of insolubility of the chitosan solved, but also the stability of the papaya-seed volatile oil is improved; the toothpaste is stable in property, has fresh and cold mouthfeel, and has the effects of improving the breath and effectively preventing the caries.

Description

technical field [0001] The invention relates to an anti-caries toothpaste and a preparation method thereof, belonging to the technical field of skin care. Background technique [0002] Caries is a common oral disease caused by a combination of multiple factors. Years of research have proved that Streptococcus mutans is the main cariogenic bacteria in humans, and its cariogenic virulence is mainly manifested on the tooth surface. Adhesion, settlement, acid production and acid resistance, and the process of its adhesion and accumulation on the tooth surface to form dental plaque biofilm is the basis of its caries. Therefore, controlling the formation of dental plaque biofilm is the key to preventing and controlling dental caries. The essential. Existing studies have found that bacteria with biofilms are more than 1,000 times more resistant to antibiotics than free bacteria, and it is difficult to remove them with ordinary disinfection methods. Plant volatile oil, also known ...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/19A61K8/34A61K8/73A61P1/02A61Q11/00
CPCA61K8/19A61K8/345A61K8/735A61K8/736A61K8/922A61Q11/00A61P1/02
Inventor 易国辉何小稳姚孟霞张菁芸陈锦萍
Owner HAINAN MEDICAL COLLEGE
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