Quantative production method for SiO2-based biological active tissue repair material

Abstract

The invention provides a quantative production method for a SiO2-based biological active tissue repair material. The method comprises the following steps: mixing water and a catalyst; adding a siliconsource precursor by a liquid charging device; adding a phosphorus source precursor by using the liquid charging device; adding a calcium source precursor by using a solid charging device; adding an inorganic salt substance containing rare earth metals by using the solid charging device; forming a wet gel and carrying out room temperature ageing; then carrying out high-temperature ageing; forminga dry gel to grind in a wet manner; and drying and screening the dry gel to finally obtain the SiO2-based biological active tissue repair material which nano porosity and high specific surface area. The preparation method is simple in step, easy to control flow, low in price of materials, needed equipment is common equipment, the single output can reach kg level, and problems of unstable batches and poor repeatability in a process of preparing powder are solved effectively.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a SiO material suitable for large-scale mass production, having nanopores and a high specific surface area. 2 Bioactive tissue repair material and preparation method thereof. Background technique [0002] The implantation of synthetic hard tissue repair materials has always been an urgent problem in the medical field. The inorganic phase of hard tissues such as bone and teeth is hydroxyapatite. The bioactive tissue repair material means that the material can form a hydroxyapatite layer on the surface of the material through a series of chemical and biological reactions in the physiological environment of the organism, which is very similar to the inorganic minerals in bones and teeth, so as to be compatible with The host bone forms a strong chemical bond, which significantly increases the bonding strength of the implant material to the bone. Therefore, this kind of bioactive...

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Problems solved by technology

[0005] However, at present, the preparation of this kind of material is mostly limited to the laboratory scale, and the single output is small, and this kind of material, whether it is used as a high-quality raw material for bioactive tissue repair materials, or directly as a powder granular product for tissue repair, has great potential. Huge market demand, so it is necessary to develop SiO with nanopores and high specific surface area 2 A large-scale preparation method of bioactive tissue repair materials, in order to expand the output, meet its use needs, promote the wider application of this material, and make it realize more important application value in tissue repair materials

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