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Application of large-dose simvastatin

A high-dose technology of simvastatin, applied in the field of western medicine, can solve the problems that have not been reported, and achieve significant anti-tumor activity, less toxic and side effects, and good anti-tumor growth effects

Pending Publication Date: 2018-12-07
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, simvastatin has not been reported in the treatment of tumors

Method used

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  • Application of large-dose simvastatin
  • Application of large-dose simvastatin
  • Application of large-dose simvastatin

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0020] The present invention can be further clearly illustrated by the specific examples given below, but they are not intended to limit the present invention.

[0021] The invention is confirmed by the following pharmacodynamic experiments. Since 15mg / kg / d, 30mg / kg / d, and 60mg / kg / d are the doses of simvastatin used in animal models. According to the doses of 15mg / kg / d, 30mg / kg / d, and 60mg / kg / d in animal models, the daily doses of simvastatin that should be used in humans are 120mg / d, 240mg / d, and 480mg / d, that is, The dosage range of the high-dose simvastatin of the present invention is 120mg / d-480mg / d.

[0022] The invention is confirmed by the following experiments.

[0023] To determine the tumor suppressor activity of simvastatin in vivo, a subcutaneous xenograft model was established. Such as figure 1 As shown, the mouse-derived breast cancer cell 4T1 was inoculated into the fat pad of BalB / C mice, and when the tumor in vivo grew to 4×4mm, 15mg / kg / d, 30mg / kg / d, 30mg / ...

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Abstract

The invention relates to simvastatin, especially relates to an application of large-dose simvastatin and belongs to the field of western medicines. The large-dose simvastatin in an in vivo model is capable of obviously inhibiting the growth of tumors, so that the large-dose simvastatin can be applied to the preparation of anti-tumor drugs, wherein the large-dose simvastatin is 120mg / d-480mg / d simvastatin.

Description

technical field [0001] The present invention relates to simvastatin (Simvastatin), in particular to the use of high-dose simvastatin. It belongs to the field of western medicine. Background technique [0002] Simvastatin was developed by Merck of the United States. It is an HMG-CoA reductase inhibitor semi-synthesized from lovastatin. Drugs for episodic hypercholesterolemia. Simvastatin is a fat-soluble substance. It can effectively prevent the development of atherosclerosis and heart disease recurrence, and reduce the risk of non-fatal myocardial infarction and myocardial revascularization. However, simvastatin has not been reported in the treatment of tumors. [0003] In the study of tumor pathogenesis, we combined pathological experiments using related mouse models and found that high-dose simvastatin has a strong inhibitory effect on the growth of solid tumors. Contents of the invention [0004] The object of the present invention is to provide the use of high-dos...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P35/00
CPCA61P35/00A61K31/366
Inventor 刘培军刘洁李娟
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV