Ratio two-photon and near-infrared HClO detection fluorescence probe as well as preparation and application thereof

A technology of near-infrared detection and fluorescent probe, which is applied in the direction of fluorescence/phosphorescence, luminescent materials, measuring devices, etc., can solve the problems of not realizing HClO ratio two-photon and near-infrared detection, and achieve simple structure, simple probe structure, The effect of high sensitivity
CN108947951AActive Publication Date: 2018-12-07SHANDONG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG NORMAL UNIV
Publication Date
2018-12-07

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Abstract

The invention relates to a ratio two-photon and near-infrared HClO detection fluorescence probe as well as preparation and application thereof and belongs to the technical fields of synthesis and detection. The structural formula of the fluorescence probe is as shown in the specification. The fluorescence probe is prepared by the following steps: 1, reacting 4-(diethylamino) salicylaldehyde with ethyl acetoacetate and piperidine; 2, enabling 4-diethylaminobenzaldehyde to participate in the reaction; and 3, enabling cyclohexene to participate in the reaction to obtain a compound, respectively reacting the compound with lithium diisopropylamide and phenylselenenyl bromide, thereby obtaining the fluorescence probe. The probe can be reacted with the HClO to produce olefinic bonds, wavelength red shift is caused by the enlarged conjugated structure, and the ratio fluorescence change of which the short wavelength fluorescence intensity is reduced and long wavelength fluorescence intensity isenhanced is formed. Therefore, the design of the probe based on the Sharpless alkene synthesis reaction can be used for detecting the HClO, and the probe is simple in structure and has the advantagesof being high in selectivity, high in sensitivity, fast in transient response and the like.
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Description

technical field

[0001] The invention belongs to the technical field of synthesis and detection, and in particular relates to a fluorescent probe for ratiometric two-photon and near-infrared detection of HClO, its preparation and application. Background technique

[0002] Hypochlorous acid (HClO) can be used as a disinfectant and oxidant in physiological processes. Endogenous HClO is usually the myeloperoxidase (MPO) secreted by immune cells during inflammatory reactions that catalyzes the generation of chloride ions and hydrogen peroxide. produced by oxidation reactions. In addition, more and more research results have shown that, in addition to phagosomes that can produce HClO under the stimulation of pathogens, non-phagosomes can also produce HClO under the induction of various soluble stimuli. The normal content of HClO can protect the organism. The imbalance of HClO, especially the excessive generation of HClO, will oxidize and destroy various biological functional mole...

Claims

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