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Uses of polysaccharide mixture in preparation of drugs for hyperglycemia

A technology for mixtures and hyperglycemia, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, etc.

Inactive Publication Date: 2018-12-11
TRINEO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since diabetes is a chronically progressive disease and no treatment to date is sufficient to reverse the course of the disease, there is a need in the related art for an improved drug that can treat disorders and / or abnormalities associated with hyperglycemia

Method used

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  • Uses of polysaccharide mixture in preparation of drugs for hyperglycemia
  • Uses of polysaccharide mixture in preparation of drugs for hyperglycemia
  • Uses of polysaccharide mixture in preparation of drugs for hyperglycemia

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0113] The preparation and analysis of embodiment 1 polysaccharide mixture of the present invention

[0114] 1.1 Submerged cultivation of Ganoderma lucidum mycelium

[0115] Ganoderma lucidum was cultured sequentially in 50, 500 and 5000 liters of sterilized medium for 3, 3 and 12-14 days according to the procedure described in the "Materials and methods" paragraph. Next, after the entire culture was sterilized, the hyphae were removed by centrifugation, the fermentation broth was collected and concentrated until the solid content was 10%, and then freeze-dried to obtain about 90 kg of polysaccharide mixture powder.

[0116] 1.2 Analysis of the polysaccharide mixture of Example 1.1

[0117] The polysaccharide mixture of Example 1.1 was analyzed for polysaccharide content and composition according to the procedure described in the "Materials and Methods" paragraph. The results show that the polysaccharide mixture of Example 1.1 has a molecular weight of at least 2,500,000 and...

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Abstract

The invention discloses novel uses of a polysaccharide mixture in preparation of drugs for treating hyperglycemia (such as diabetes) and / or abnormalities associated with hyperglycemia, wherein the polysaccharide mixture has a molecular weight of at least 500000, and has about 30-50% by weight of beta (1[arrow]3) glucan and beta (1[arrow]6) glucan. According to the present invention, the polysaccharide mixture is administered to a to-be-treated individual at a dose of about 1-1000 mg / kg / day so as to alleviate or retard the symptoms associated with hyperglycemia.

Description

technical field [0001] The present disclosure relates to the use of a polysaccharide mixture for the prevention and / or treatment of hyperglycemia-related disorders (eg, diabetes). Background technique [0002] Diabetes is a disease in which an individual's body does not produce enough insulin or does not respond appropriately to insulin. Insulin is a hormone produced by the pancreatic body to prompt cells to convert glucose into energy for use by an individual's body. When insulin is insufficient or the body cannot respond to insulin properly, glucose builds up in the blood and can lead to various complications. Diabetes is known to come in many forms, but three of them are the most well known: Type I and II diabetes and gestational diabetes. In addition, prediabetes is defined as a hyperglycemic state prior to diabetes, where blood sugar levels are higher than normal, but not high enough to be diagnosed as diabetes. [0003] Type I diabetes or insulin-dependent diabetes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10
CPCA61K31/715A61K36/074A61K2300/00
Inventor 黄政博曹正秋章肇轩陈登海黄立铭林界宏
Owner TRINEO BIOTECH