Polymer loaded with penicillin and nitric oxide and its preparation method and application
A technology of nitric oxide and penicillin, applied in the field of biomedical engineering, achieves the effects of good biocompatibility, high density of secondary amine groups, and increased loading
Active Publication Date: 2021-07-27
JINAN UNIVERSITY
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Problems solved by technology
So far, polymer materials and their applications that can simultaneously achieve high loading of penicillin and nitric oxide have not been reported
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0049] Referring to Example 4 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendritic polyamide-amine (CS-PAMAM) was prepared.
Embodiment 2
[0051] Referring to Example 5 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendrimer polyamide-amine (CS-PAMAM) was prepared.
Embodiment 3
[0053] Referring to Example 6 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendritic polyamide-amine (CS-PAMAM) was prepared.
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The invention belongs to the field of biomedical engineering, and discloses a polymer simultaneously loaded with penicillin and nitric oxide, a preparation method and application thereof. The structural formula of this polymer is as follows. The present invention selects polyamide-amine dendritic molecule PAMAM, which is a dendritic cation containing an alkyne group, as the NO donor. Its single-branched structure and a large number of secondary amines in the structure are conducive to the efficient loading of NO. In addition, PAMAM also contains a large number of primary amine groups, which is conducive to the efficient loading of penicillin and the efficient loading of NO and PCN. Grafting chitosan with polyamide-amine can greatly improve the biocompatibility of the material, and the high grafting rate of chitosan long chain to polyamide-amine also greatly improves the loading capacity of NO and PCN; and The antibacterial effect of the polymer loaded with penicillin and NO at the same time is better than that of single loaded penicillin or NO, resulting in a synergistic effect.
Description
technical field [0001] The invention belongs to the field of biomedical engineering, in particular to a polymer simultaneously loaded with penicillin and nitric oxide, a preparation method and application thereof. Background technique [0002] According to the 2014 CHINET China Bacterial Resistance Surveillance Report, bacterial drug resistance is still on the rise, and the emergence and increasing of multidrug-resistant, extensively drug-resistant and fully drug-resistant strains have brought challenges to anti-infective treatment. Antibiotic resistance has become a serious problem of global concern and a hot topic of scientific research. [0003] Research results in recent years have revealed that the problem of antibiotic resistance is not only related to the large number of drug-resistant strains, but also closely related to the growth of pathogenic bacteria in the form of biofilm in the human body. Biofilm is a highly structured film-like complex formed by bacteria adh...
Claims
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IPC IPC(8): A61K47/59A61K47/61A61K31/43A61K33/00A61P31/04
CPCA61K31/43A61K33/00A61K47/595A61K47/61A61P31/04A61K2300/00
Inventor 马栋刘施欣张武胡云峰薛巍
Owner JINAN UNIVERSITY
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