Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cell nucleus segmentation method and system for fluorescence in situ hybridization images

A technology of fluorescence in situ hybridization and cell nucleus, which is applied in the field of cell nucleus segmentation method and system of fluorescence in situ hybridization image, which can solve the problems of blurred nucleus edge and cell adhesion, so as to improve the quality of segmentation, improve over-segmentation, and improve the accuracy rate Effect

Active Publication Date: 2020-11-10
柯凯
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the technical problems of fuzzy nuclei in FISH images and difficult identification of cell nuclei and cell adhesion in the images in the prior art, the present invention proposes a cell nucleus segmentation method and system for fluorescence in situ hybridization images

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cell nucleus segmentation method and system for fluorescence in situ hybridization images
  • Cell nucleus segmentation method and system for fluorescence in situ hybridization images
  • Cell nucleus segmentation method and system for fluorescence in situ hybridization images

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, but these embodiments should not be construed as limiting the present invention.

[0042] The present invention proposes a flow process of a cell nucleus segmentation method for fluorescence in situ hybridization images as follows: figure 1 Shown, is for a given FISH image of breast cancer (such as figure 2 shown) to find the process of the nucleus region, the specific steps include:

[0043] 1) The preprocessed FISH image (such as image 3As shown), the pixel value of each pixel of the red, green, and blue three-channel images in the image is reduced by adt_value to ensure that any position of the image is still greater than or equal to 0 after the reduction, and the overall displacement of the image is realized; the value range of adt_value is [2050 ] pixels. Collect the red channel and green channel in the three-channel image where the pi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a cell nucleus segmentation method and system for fluorescence in situ hybridization images. The method realizes the identification of cell nuclei in FISH images through preprocessing, binarization, hole filling, morphological operations, secondary watershed and other processing processes. ,segmentation. The system includes a FISH image receiving module, an image preprocessing module, a cell nucleus detection module and a report generating module. When segmenting FISH images of breast cancer, gastric cancer and other cancer cells to obtain the cell nucleus area, the present invention can reduce the image fluorescence scattering effect through multiple preprocessing, which can effectively improve the problem of over-segmentation in direct watersheds, thereby improving FISH Segmentation quality of image recognition cells.

Description

technical field [0001] The invention relates to the technical field of medical pathology analysis, which uses a computer image processing method to automatically identify cell nucleus regions in fluorescence in situ hybridization images, and more specifically refers to a method and system for segmenting cell nuclei in fluorescence in situ hybridization images. Background technique [0002] In the field of cancer treatment, such as breast cancer and gastric cancer, the targeted drug Herceptin has the characteristics of high efficiency, low toxicity and strong selectivity. It is a human source of high-purity recombinant DNA derivatives targeting Her-2 / neu receptors Monoclonal Antibodies. Since the targeted drug Herceptin is only effective for breast cancer with HER2 amplification, accurate detection of HER2 amplification is an absolute prerequisite for clinical application of Herceptin, and is also the premise and key to successful targeted therapy. For clinical routine and r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/00G06T7/11G06T5/00G06T7/90
CPCG06T7/0012G06T7/11G06T7/90G06T2207/30024G06T5/92G06T5/80G06T5/70
Inventor 刘娟陈哲袁静萍汤永飞贺华段慧芳
Owner 柯凯
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com