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Cancer cell her2 gene amplification analysis method and system

A technology of gene amplification and analysis method, applied in the field of HER2 gene amplification analysis method and system in cancer cells, can solve the problems of blurred edge of cell nucleus and low recognition rate of HER2 gene amplification, so as to improve segmentation quality and improve over-segmentation. , the effect of improving the accuracy

Active Publication Date: 2020-11-10
柯凯
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Problems solved by technology

[0004] Aiming at the technical problems in the prior art that the nucleus edge of the FISH image is blurred and difficult to identify, and the cell adhesion in the image leads to a low recognition rate of HER2 gene amplification, the present invention proposes a cancer cell HER2 gene amplification analysis method and system, Used for HER2 gene amplification analysis on FISH images, and output FISH test result report

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  • Cancer cell her2 gene amplification analysis method and system
  • Cancer cell her2 gene amplification analysis method and system
  • Cancer cell her2 gene amplification analysis method and system

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[0054] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, but these embodiments should not be construed as limiting the present invention.

[0055] Such as figure 1 As shown, a kind of cancer cell HER2 gene amplification analysis method proposed by the present invention, the specific steps include:

[0056] 1) Perform red dot clustering analysis on the red channel image of the FISH image. If the total number of single red dot clusters exceeds the set value, it is directly determined as HER2 gene amplification, and go to step 7), otherwise go to step 2).

[0057] The analysis method of clustering red dots is:

[0058] 11) separate the red channel of the input FISH image to obtain the red channel image;

[0059] 12) Perform morphological operations on the red channel image, use structural elements to perform top-hat operations on the red channel, and the radius of the structural elements is 80, elimina...

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Abstract

The invention discloses a cancer cell HER2 gene amplification analyzing method and system. According to the invention, the method comprises: carrying out red dot cluster analysis; carrying out red dotrecognition; carrying out green dot recognition; constructing a cell nucleus character matrix; carrying out segmentation to obtain an area and a circularity value of a cell nucleus; calculating a mean ratio value, a mean green dot value, and a mean red dot value of each cell; determining the HER2 gene is amplified; and outputting a FISH test result report based on determination of HER2 gene amplification. According to the invention, the HER2 gene amplification detection and analysis are carried out by using the cancer cell FISH image; with simulation of the pathologist diagnostic process, thered-dot and green-dot ratio values of the FISH image can be identified effectively by the computer and thus whether the HER2 gene is amplified is determined; and thus the workload for the pathologistis reduced.

Description

technical field [0001] The invention relates to the technical field of medical pathological analysis, which uses computer image processing technology to analyze the detection results of cancer cells, and more specifically refers to a cancer cell HER2 gene amplification analysis method and system. Background technique [0002] In the field of cancer treatment, such as breast cancer and gastric cancer, the targeted drug Herceptin has the characteristics of high efficiency, low toxicity and strong selectivity. It is a human source of high-purity recombinant DNA derivatives targeting Her-2 / neu receptors Monoclonal Antibodies. Since the targeted drug Herceptin is only effective for breast cancer with HER2 amplification, accurate detection of HER2 amplification is an absolute prerequisite for clinical application of Herceptin, and is also the premise and key to successful targeted therapy. For clinical routine and research, the most widely used techniques are immunohistochemistry...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/20G06T7/00G06T7/11G06T7/62
CPCG06T7/0012G06T7/11G06T7/62G06T2207/10056G06T2207/30004G16H50/20
Inventor 刘娟陈哲袁静萍汤永飞贺华段慧芳
Owner 柯凯
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