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Pain-relieving spray for external use and preparation method thereof

A technology for external use of analgesics and extracts, applied in the field of external drugs, can solve the problems of many adverse reactions, unsatisfactory effects, low safety, etc., and achieve the effects of good safety, blocking pain signal transmission, and rapid onset of action

Active Publication Date: 2018-12-18
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of slow onset of action, unsatisfactory effect, many adverse reactions, and low safety of existing externally used analgesic drugs, the present invention provides a drug that is safe in use, wide in application, rapid in effect, definite in curative effect, and low in cost. topical analgesics

Method used

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  • Pain-relieving spray for external use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] An analgesic for external use is made from the following raw materials in parts by weight:

[0032] Menthol 12, bamboo cypress extract 15, capsaicin 0.2, dimethyl sulfoxide 20, green skewer extract 10, winter green oil 10, turpentine oil 10, calendula oil 5, hypericum oil 5, camphor 0.8, two Methylsulfone 1, Ginger Oil 1, Olive Oil 1.

[0033] The preparation method is as follows:

[0034] (1) Preparation of bamboo and cypress extract: remove impurities from bamboo and cypress leaves, wash, dry and crush, add 4 times the amount of isobutanol, soak for 2 hours and filter, discard the filtrate, dry the filter residue and add 10 times the amount therein Acetic acid aqueous solution with a volume concentration of 0.6%, soaked for 1 hour, decocted for 0.5 hour, filtered the liquid medicine, and the filtrate was used for later use. Under the same conditions, the filter residue was repeatedly extracted once, filtered, and the filtrates were combined twice, and concentrated un...

Embodiment 2

[0038] An analgesic for external use is made from the following raw materials in parts by weight:

[0039] Menthol 10, bamboo and cypress extract 12, capsaicin 0.18, dimethyl sulfoxide 18, green skewer extract 8, winter green oil 8, turpentine oil 8, calendula oil 4.5, hypericum oil 4.5, camphor 0.65, two Methyl sulfone 0.9, ginger oil 0.9, olive oil 0.8.

[0040]The preparation method is the same as in Example 1.

Embodiment 3

[0042] An analgesic for external use is made from the following raw materials in parts by weight:

[0043] Menthol 13, bamboo cypress extract 16, capsaicin 0.25, dimethyl sulfoxide 22, green skewer extract 12, winter green oil 12, turpentine oil 12, calendula oil 5.5, hypericum oil 5.5, camphor 0.9, di Methyl sulfone 1.2, ginger oil 1.2, olive oil 1.5.

[0044] The preparation method is the same as in Example 1.

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Abstract

The invention relates to the field of medicine for external use, in particular to a pain-relieving spray for external use. The pain-relieving spray for the external use is prepared from menthol, podocarpus nagi extract liquid, capsaicine, dimethyl sulfoxide, picea wilsonii extract liquid, methyl salicylate, turpentine, calendula oil, hypericum oil, camphor, dimethyl sulfone, ginger oil and olive oil. By improving a formula, the ingredients such as the menthol, the capsaicine, the dimethyl sulfoxide, the methyl salicylate and, turpentineand the like are synergistically cooperated, and by addingthe podocarpus nagi extract liquid and thepicea wilsonii extract liquid prepared in a specific process, the pain-relieving spray for the external use can rapidly permeate the surface skin to reach apainful part, so that the transfer of the pain signal can be effectively blocked, and an effect for rapidly relieving the pain can be realized. The pharmacological test proves that the pain-relievingspray for the external use has an ideal curative effect for the peripheral pain; and moreover, the product provided byof the invention is rapid in effectiveness, convenient in use, good in safety, andsuitable for the clinical requirement at present.

Description

technical field [0001] The invention relates to the field of medicine for external use, in particular to an analgesic for external use and a preparation method thereof. Background technique [0002] Analgesics refer to drugs that can relieve pain partially or completely, mainly including non-steroidal anti-inflammatory drugs and central analgesics. According to different routes of administration, analgesics can be divided into oral analgesics and topical analgesics. Currently, commonly used topical analgesics include Voltaren ointment, ibuprofen ointment, diclofenac sodium ointment, Yunnan Baiyao, and traditional Chinese medicine ointment. Muscle and joint pain, sports sprains, and pain caused by various types of inflammation. [0003] However, the above-mentioned various types of drugs still show many deficiencies in the clinical application process. For example, although the non-steroidal anti-inflammatory drugs have a rapid onset of action, they have many adverse reactio...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P29/00A61K31/045A61K31/125A61K31/165A61K31/618
CPCA61K9/0014A61K31/045A61K31/125A61K31/165A61K31/618A61K36/15A61K36/28A61K36/32A61K36/38A61K36/9068A61K2236/331A61K2236/53A61P29/00A61K2300/00
Inventor 李长润于小利
Owner ANHUI UNIVERSITY
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