A kind of biodegradable Zn-Mo system zinc alloy and preparation method thereof

A biodegradable, zinc alloy technology, applied in the field of medical implant materials, can solve the problems of not being suitable for the use of medical implant materials, achieve the effect of improving mechanical properties and biological functionality, promoting repair and healthy operation

Active Publication Date: 2021-01-15
北京尚宁科智医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Similar to the zinc alloy in Patent Document 1, this zinc alloy contains a large amount of Al and Ni elements that are harmful to the human body, and is not suitable for use as a medical implant material

Method used

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  • A kind of biodegradable Zn-Mo system zinc alloy and preparation method thereof
  • A kind of biodegradable Zn-Mo system zinc alloy and preparation method thereof
  • A kind of biodegradable Zn-Mo system zinc alloy and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0054]The composition, preparation and performance test of biodegradable Zn-Mo-Mn ternary zinc alloy.

[0055]The chemical compositions of the four invention examples of the zinc alloy are as shown in Table 1-1, the total amount of added alloying elements does not exceed 0.8%, and the balance is Zn, which is a low-alloy zinc alloy with low cost. The preparation process of the zinc alloy is: smelting Mn-10Mo master alloy→smelting Zn-Mo-Mn ternary zinc alloy→hot rolling→heat treatment→cold rolling. The smelting of the Mn-10Mo master alloy uses high-purity Mo and Mn powder as raw materials, batches according to the mass percentage, Mn content 90% and Mo content 10%, mixed and placed in a vacuum induction furnace, vacuumed and heated The temperature is raised to 1500° C., the temperature is kept for 15 minutes, and the Mn-10Mo master alloy is obtained by pouring into a casting mold. The smelting of the Zn-Mo-Mn ternary zinc alloy uses the Mn-10Mo master alloy and high-purity Zn block as ra...

Embodiment 2

[0066]The composition, preparation and performance test of the biodegradable Zn-Mo-Mn-Ti-Li five-element alloy.

[0067]The chemical composition of the four invention examples of the zinc alloy is as shown in Table 2-1, the total amount of added alloying elements does not exceed 1.2%, and the balance is Zn, which is a low-alloy zinc alloy with low cost. The preparation process of the zinc alloy is: smelting Mn-20Mo-5Ti master alloy → smelting Zn-Mo-Mn-Ti-Li five-element zinc alloy → hot extrusion → heat treatment → hot extrusion. The smelting of the Mn-20Mo-5Ti master alloy uses high-purity Mn, Mo and Ti powders as raw materials, batches according to the mass percentage of 75% Mn, 20% Mo and 5% Ti, and puts them in a vacuum induction furnace after mixing. After vacuuming, the temperature is raised to 1600° C., the temperature is kept for 10 minutes, and then poured into a mold to obtain the Mn-20Mo-5Ti master alloy. The smelting of the Zn-Mo-Mn-Ti-Li five-element zinc alloy uses the Mn...

Embodiment 3

[0076]Composition, preparation and performance test of biodegradable Zn-Mo quaternary zinc alloy.

[0077]The zinc alloy contains 4 kinds of alloying elements, of which 3 kinds are necessary alloying elements: Zn, Mo and Mn, and the fourth kind is a further added alloying element. The chemical composition of the four embodiments of the zinc alloy is as shown in Table 3-1, the total amount of added alloying elements does not exceed 0.81%, and the balance is Zn, which is a low-alloy zinc alloy with low cost. The preparation process of the zinc alloy is: smelting Mn-30Mo master alloy→smelting Zn-Mo quaternary zinc alloy→hot extrusion→heat treatment→cold rolling. The smelting of the Mn-30Mo master alloy uses high-purity Mo and Mn powder as raw materials, and mixes them in a mass percentage of 70% Mn and 30% Mo. After mixing, they are placed in a vacuum induction furnace, and the temperature is raised to 1700°C after being vacuumed. 10 minutes, then pouring into a casting mold to obtain the...

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Abstract

The invention relates to a biodegradable Zn-Mo zinc alloy, and belongs to the field of medical implant materials. The biodegradable Zn-Mo zinc alloy comprises the compositions of 001-3% of Mo, 0. 001-6% of Mn; then at least one of the elements containing Li, Na, K, C, Ce, La, Pr, Nd, Sm, Ho, Er, Gd, Lu, Sn, P, B, Se, Zr, Ca, Mg, Fe, Cu, Ag and Sr is selected, and total amount of alloying elementsadded can be optimized to control no more than 1.5% with the balance being Zn. The uniform distribution of Zn and refractory elements Mo, Ti and Ta in Zn matrix can be realized by exciting the metallurgical action of at least one element in Mn rich intermediate alloy. The preparation process of the zinc alloy is as follows: smelting rich Mn intermediate alloy smelting Zn Mo series zinc alloy deformation heat treatment. The preparation process of the zinc alloy comprises that smelting Mn-rich intermediate alloy; smelting Zn- Mo based zinc alloy; and deformation heat treatment. Yield strength of the zinc alloy is 100-550MPa, tensile strength is 150-750MPa, and elongation is 1. 3-104%; a degradation rate in the simulated body fluid does not exceed 0.8 mm / year; the cytotoxicity of L929 cellsand human bone marrow mesenchymal stem cells is level 0 or level 1, shows good biocompatibility, and can be used in a variety of medical implants.

Description

Technical field[0001]The invention relates to the component design, preparation method and application field of a biodegradable Zn-Mo series zinc alloy, and belongs to the field of medical implant materials.Background technique[0002]The main traditional use of metallic zinc is as a coating to prevent steel corrosion. In recent years, research on zinc and zinc alloys as a new generation of biodegradable metals has emerged at home and abroad. The corrosion rate of zinc is between iron and magnesium, and the degradation rate in the organism is moderate. It has biological safety and can be used as a medical implant material. However, pure zinc is relatively soft and has a tensile strength of only 120MPa, which makes it difficult to be used in the manufacture of medical implants that require stress, such as coronary stents and bone nails. In addition, the common problem of as-cast pure zinc and zinc alloys is extremely brittle, and the room temperature elongation is usually not more than...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C18/00C22C1/03C22F1/16
CPCC22C1/03C22C18/00C22F1/165
Inventor 石章智王鲁宁刘雪峰于静
Owner 北京尚宁科智医疗器械有限公司
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