A Population Protein Structure Prediction Method Based on Dynamic Fragment Length
A protein structure and prediction method technology, applied in the field of population protein structure prediction based on dynamic fragment length, can solve the problems of low prediction accuracy and search efficiency, and achieve the effect of maintaining diversity, speeding up the interaction process, and speeding up the search speed.
Active Publication Date: 2021-06-18
ZHEJIANG UNIV OF TECH
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[0006] In order to overcome the shortcomings of low prediction accuracy and search efficiency of existing protein structure prediction methods, the present invention proposes a group protein structure prediction method based on dynamic fragment length with high prediction accuracy and search efficiency
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[0031] The present invention will be further described below in conjunction with the accompanying drawings.
[0032] refer to Figure 1 ~ Figure 3 , a population protein structure prediction method based on dynamic fragment length, comprising the following steps:
[0033] 1) Input the sequence information of the protein to be tested, and obtain the fragment library from the ROBETTA server (http: / / www.robetta.org / );
[0034] 2) Parameter setting: set the population size NP, the crossover probability CR, the temperature factor KT, and the maximum number of iterations G max , fragment length set l={l 1 , l 2 ,...,l M}, the selection probability p of each segment length m , m=1,2,...,M, and initialize the number of iterations g=0, where M is the scale of the segment length set;
[0035] 3) Randomly select fragments from the fragment library corresponding to each residue to assemble to generate the initial conformation population P initial ={C 1 ,C 2 ,...,C NP}, where C ...
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A population protein structure prediction method based on dynamic fragment length. For each target conformation, half of the conformation individuals are randomly selected from the current population to establish a subpopulation, and the population is sorted according to the energy value, and the top-ranked conformation is randomly selected. A conformation to guide the mutation; in the mutation process, multiple fragment lengths are designed, and the probability of being selected is calculated according to the success rate of each fragment length in the early stage, and then a fragment length is selected based on the selection probability according to the roulette method Fragment exchange is performed to realize the mutation process. The invention provides a group protein structure prediction method based on dynamic segment length with high prediction accuracy and search efficiency.
Description
technical field [0001] The invention relates to the fields of biological informatics, intelligent optimization and computer application, and in particular to a group protein structure prediction method based on dynamic fragment length. Background technique [0002] In 1965, Nirenberg and Khorana discovered the triplet genetic code (that is, the first genetic code). DNA is translated into a protein amino acid sequence (that is, the primary structure of the protein) with a codon of three nucleotides; Only by forming a specific three-dimensional structure (that is, the tertiary structure of the protein) can its specific biological function be produced. Relative to the first genetic code, the correspondence between the primary structure of a protein sequence and its tertiary structure (ie, the second genetic code or folding code) remains an unsolved mystery. In order to solve the "problem of the century" of protein folding, more and more researchers with different disciplinary ...
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IPC IPC(8): G16B20/00
Inventor 周晓根张贵军彭春祥胡俊刘俊
Owner ZHEJIANG UNIV OF TECH