Unlock instant, AI-driven research and patent intelligence for your innovation.

Fasting mimicking diet (FMD) as immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases.

An autoimmune, inflammatory disease technology for the treatment and reversal of inflammatory bowel disease and other gastrointestinal autoimmune and inflammatory diseases that addresses high cost, long-term safety studies, monoclonal therapy or combination Controversy over therapeutic efficacy

Pending Publication Date: 2019-01-04
UNIV OF SOUTHERN CALIFORNIA
View PDF16 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Current therapies for gastrointestinal autoimmune / inflammatory diseases are monoclonal antibodies or a combination of monoclonal antibodies and immunomodulatory therapy; however, the efficacy of monoclonal therapy or combination therapy remains controversial, and its long-term safety remains uncertain. to be studied 12-14
Furthermore, the number of effective mAbs, infusion reactions, immunogenicity, high cost and adverse events such as lymphoma or acute allergy limit their use 15,16

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fasting mimicking diet (FMD) as immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases.
  • Fasting mimicking diet (FMD) as immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases.
  • Fasting mimicking diet (FMD) as immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Reference will now be made in detail to presently preferred compositions, embodiments and methods of the invention, which constitute the best modes presently known to the inventors for carrying out the invention. The drawings are not necessarily drawn to scale. It is to be understood, however, that the disclosed embodiments are merely exemplary of the invention, which may be embodied in various and alternative forms. Therefore, specific details disclosed herein are not to be interpreted as limiting, but merely as a representative basis for any aspect of the invention and / or as a representative basis for teaching one skilled in the art to variously employ the invention.

[0020] Except in the examples or where otherwise expressly indicated, all quantities in this specification expressing quantities of substances or reaction conditions and / or uses are to be understood as modified by the word "about" describing the broadest scope of the invention. Practice within the nume...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A method for treating autoimmune and / or inflammatory diseases includes a step of identifying a subject having a gastrointestinal autoimmune / inflammatory disease. A fasting mimicking diet (FMD) is administered to the subject for a first time period.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 62 / 334,733, filed May 11, 2016, the disclosure of which is incorporated herein by reference in its entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with government support under Contract No. P01AG034906 awarded by the National Institutes of Health / National Intelligence Agency. The government owns certain rights in inventions. technical field [0005] The present invention generally relates to methods of treating and reversing inflammatory bowel disease (IBD), including both Crohn's disease and ulcerative colitis, and other autoimmune and inflammatory diseases of the gastrointestinal tract, in part by reducing, preventing, or Reversal of both innate and adaptive immune responses proceeds, and in part by promoting intestinal regeneration. Background technique [0006] Autoimmu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/70A61K38/00A61K31/51A61K31/07A61K31/202
CPCA23L33/00A23L33/30A23V2002/00A23L33/40A61P29/00A61K45/06A23V2200/32A61K31/07A61K31/202A61K31/51A61K31/70A61K38/00A61P1/00
Inventor 瓦尔特·D·隆哥崔仁荣
Owner UNIV OF SOUTHERN CALIFORNIA