A degradable gradient pore mammary gland scaffold

Abstract

A gradient-degradable porous breast stent is composed of a three-dimensional boundary structure and an internal filling structure, wherein the shape of the three-dimensional boundary structure is matched with the contour of the actual tumor of the implanted patient; and the internal filling structure is a gradient pore structure obtained by multi-layer lattice structure with different size, and the pore size gradually decreases from outside to inside. The gradient-degradable porous breast stent is prepared by adopting biodegradable material, and after being implanted into the human body, the gradient-degradable porous breast stent can not only repair the breast shape of the patient, but also can match the mechanical stability of the stent and the tissue regeneration process at the initialstage of implantation, and the porous structure is conducive to the growth of tissue cells, easy operation and fixation, cell proliferation and differentiation in the corresponding growth environmentin vivo, stent degradation, autologous tissue growth and infiltration so as to completely replace the implant, to restore the natural breast shape and touch effect.

Description

technical field [0001] The invention relates to the technical field of tissue engineering and biomanufacturing, in particular to a degradable gradient pore mammary gland support. Background technique [0002] Breast reconstruction surgery can alleviate the physical and psychological discomfort of patients after mastectomy, improve the quality of life, and is accepted by more and more patients. Existing breast reconstruction operations include implant reconstruction and autologous tissue reconstruction. The above two breast reconstruction methods have inherent defects. Implantation of non-degradable prostheses such as silicone may cause rejection in the body, leading to complications such as capsular contracture. autologous adipose tissue transplantation also has problems such as lack of blood supply to the implanted tissue, resulting in fat reabsorption and low transplantation efficiency (40%-70% volume loss). [0003] The applicant once proposed an invention patent for a d...

AI Technical Summary

Problems solved by technology

This type of scaffold is prone to irreversible deformation when it lacks autologous tissue as an auxiliary support inside. In other words, the mechanical stability of this type of scaffold cannot match the breast tissue regeneration process

Images