Device for monitoring intracranial wound healing, its preparation method and application

A wound healing and monitoring device technology, applied in applications, printing devices, diagnostic recording/measurement, etc., can solve the problems of inability to realize real-time imaging of tissue wounds, unavailability of long-term observation, and long time to generate images.

Active Publication Date: 2021-09-10
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual use, MRI imaging needs the help of a strong magnetic field, and it takes a long time to generate images, so real-time imaging of tissue wounds cannot be achieved; CT imaging generates a large amount of radiation during use, and cannot be used for long-term observation

Method used

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  • Device for monitoring intracranial wound healing, its preparation method and application
  • Device for monitoring intracranial wound healing, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0045] This embodiment is used to illustrate the processing and preparation method of the flexible brain electrode array of the present invention, which includes the following steps:

[0046] Add 4 grams of liquid metal (indium-gallium alloy, 75.5% gallium mass fraction, 24.5% indium mass fraction) and 1 ml n-decanol into a 5 ml centrifuge tube. The liquid metal micro-nano particles can be prepared by ultrasonicating the ultrasonic cell breaker at 20% intensity for 2 minutes, and the prepared liquid metal ink is added to the screen printing template, and the pattern of the electrode array is printed. Next, cast the pre-cured PDMS (PDMS: curing agent = 10:1) onto the electrode array pattern, put the electrodes in an oven at 80 degrees Celsius to cure for 2 hours, and after the PDMS is completely cured, peel off the PDMS from the substrate A flexible brain electrode array can be obtained. The PDMS is poured on the PET substrate, and after curing is complete, the PDMS is peeled ...

Embodiment 2

[0048] This test example is used to illustrate the flexible electrode array combined with the photoacoustic imaging system to monitor the condition of intracranial wounds, including the following steps:

[0049]Rats are used as experimental subjects, and brain tissue wounds in specific areas of rats are monitored. After the rat was anesthetized, a 2 cm x 2 cm opening was made on the cranium. After the dura was removed, the surface layer was completely exposed. The flexible electrode prepared in Example 1 was attached to the cerebral cortex. The flexible electrode was compatible with the commercial EEG system. connected to monitor changes in EEG signals in the area. At the same time, the photoacoustic imaging system is used to accurately image the monitoring site in real time. The photoacoustic imaging system probe is aimed at the middle area of ​​the brain tissue, the electrode array detects peripheral EEG signals, and the photoacoustic imaging system performs real-time imagin...

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Abstract

The invention provides an intracranial wound healing monitoring device, its preparation method and application. The device comprises: a flexible electrode array and a photoacoustic imaging system. The flexible electrode array based on liquid metal has high biological safety and low elastic modulus, and can be closely attached to the surface of cortical wounds to detect high-resolution EEG signals; the photoacoustic imaging system not only has high detection accuracy , no damage to the tissue, and safe and convenient, is an important advancement in medical imaging-aided diagnosis; combined with flexible brain electrode arrays and photoacoustic imaging systems, it overcomes the problem that intracranial wounds cannot be observed, and realizes non-invasive monitoring of intracranial wounds. The accuracy can even meet the requirements of clinical monitoring indicators.

Description

technical field [0001] The invention belongs to the field of intracranial wound monitoring, and in particular relates to an intracranial wound healing monitoring device, its preparation method and application. Background technique [0002] At present, there is no effective monitoring method for intracranial trauma, which is a major problem in clinical treatment. Timely and accurate monitoring of intracranial wound healing is not only conducive to early detection of changes in intracranial wounds and improvement of treatment effects, but also has very important significance for clinical diagnosis and guidance of treatment. Implantable brain electrodes can effectively monitor the electrical signals of brain tissue, so that the wound healing can be judged according to the changes of the brain electrical signals. Among them, the brain electrode array is an important brain-computer interface for monitoring EEG signals, which can establish a direct communication channel between t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B5/291A61B5/263B41M1/12
CPCA61B5/0086A61B5/0095A61B2562/0209A61B2562/125A61B5/291B41M1/12
Inventor 蒋兴宇董瑞华奚磊秦伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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