Nano-medicine of biogenic macrocyclic molecule and preparation method of nano-medicine
A technology of nano-drugs and macrocyclic molecules, which can be applied to medical preparations with non-active ingredients, polymer compounds with non-effective ingredients, medical preparations containing active ingredients, etc. It can solve the problem of loss of tumor self-protection barrier and short circulation time in the body , damage to organ functions and other issues, to achieve good anti-tumor effect, excellent anti-tumor performance, and the effect of inhibiting the ring opening of lactone
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Embodiment 1
[0052] This embodiment provides a kind of nanomedicine of biological source macrocyclic molecule (the nanomedicine number of the biological source macrocyclic molecule provided by this embodiment is SN38-ND), which comprises SN38 and transports phospholipid nanodiscs of SN38, and the phospholipid nanodisks are The two MSPs are connected head-to-tail to the outside of the phospholipid molecule - DMPC. The helical conformations of the two MSPs are parallel to the phospholipid molecule, and the hydrophobic residues of the MSP are located inside the helical conformation.
[0053] The present embodiment provides a method for preparing a nanomedicine of a biological source macrocyclic molecule, comprising the following steps:
[0054] 100 mg of DMPC was dissolved in 10 mL of a mixed solution of chloroform and methanol (chloroform: methanol = 3:1, v / v). Divide into 10 parts, dry in vacuum for 4h, use N 2 Blow dry slightly and store at -20°C. When using, take 1 portion of DMPC, the ...
Embodiment 2-4
[0058] The nano-drugs of bio-derived macrocyclic molecules provided in Examples 2-4 have the same basic structure as the nano-drugs of bio-derived macrocyclic molecules provided in Example 1, except that the raw materials used are different. The basic operation of the preparation method of the nano-medicine of the bio-derived macrocyclic molecule provided in Examples 2-4 is the same as the preparation method of the nano-medicine of the bio-derived macrocyclic molecule provided in Example 1, except that the specific operating conditions are different.
Embodiment 2
[0060] The nano-medicine of biological source macrocyclic molecule adopts phosphatidylcholine as the phospholipid molecule.
[0061] Every milligram of phospholipid molecules is dissolved in a mixed solution of 0.15 milliliters of chloroform and methanol, the concentration of the phospholipid molecular solution is 8 mg / mL, and the buffer is 18 mM, pH=3.0 sodium acetate buffer solution. The concentration of the drug solution is 4mg / mL, the volume ratio of the drug solution to the phospholipid molecular solution is 1:3, the shaking temperature is 20°C, and the shaking time is 5 hours. The concentration of the protein solution was 4 mg / mL, the volume ratio of the protein solution to the first mixed solution was 1:1.25, and the ultrasonic temperature was 22°C.
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