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Application of diosmin in preparation of medicine for preventing and/or treating hyperuricemia nephropathy

A technology of hyperuricemia and diosmin, applied in the field of biomedicine, can solve the problems of patients' intolerance, limited clinical use, and large toxic and side effects

Active Publication Date: 2020-10-02
WUHAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims at the defects of existing medicines for treating hyperuricemia nephropathy with large toxic and side effects, difficult tolerance of patients, and limited clinical use, and aims to develop an anti-hyperuricemia nephropathy medicine with high efficiency and low toxicity, so as to solve the current problems. Toxicity of clinically used drugs, improving patient tolerance and compliance

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  • Application of diosmin in preparation of medicine for preventing and/or treating hyperuricemia nephropathy
  • Application of diosmin in preparation of medicine for preventing and/or treating hyperuricemia nephropathy
  • Application of diosmin in preparation of medicine for preventing and/or treating hyperuricemia nephropathy

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Embodiment Construction

[0019] Preferred embodiments of the present invention will be described in more detail below. Although preferred embodiments of the present invention are described below, it should be understood that the present invention can be embodied in various forms and should not be limited by the embodiments set forth herein.

[0020] The present invention is studied using in vitro and in vivo methods.

[0021] 1. Inhibitory effect of diosmin on xanthine oxidase in vitro

[0022] 1.1 Materials

[0023] 1.1.1 Drugs and reagents

[0024] Diyerin (purity ≥ 97%), batch number D17081604, purchased from Nanjing Dierge Pharmaceutical Technology Co., Ltd.; dipotassium hydrogen phosphate (analytical pure), purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; anhydrous potassium dihydrogen phosphate (analytical Pure), purchased from Guangfu Institute of Fine Chemicals, Tianjin; EDTA-2Na (analytical pure), purchased from Biosharp; xanthine (purity 98%, batch number: D1606030), purchased fr...

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Abstract

The invention belongs to the field of biomedicine, and in particular relates to the application of diosmin in the preparation of medicines for preventing and / or treating hyperuricemia nephropathy. The single use of diosmin or the combination of diosmin and allopurinol can not only reduce the serum uric acid in mice with hyperuricemia and nephropathy, but also significantly reduce the levels of serum urea nitrogen and creatinine, and at the same time reduce the level of serum urea nitrogen and creatinine. The kidney index of mice caused by uricemia increased significantly, and the spleen index also increased significantly, indicating that the combination of the two drugs can reduce uric acid in mice with hyperuricemia and nephropathy, and at the same time reverse the impairment of kidney function in mice caused by elevated serum uric acid. damage, and then protect the kidney function of mice with hyperuricemia, and have a protective effect on their immune system.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and more specifically relates to the application of diosmin in the preparation of medicines for treating hyperuricemia nephropathy, and the active component is diosmin alone or a drug combination of diosin and allopurinol Combination of diosmin and allopurinol in the preparation of medicine for treating hyperuricemia nephropathy. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of asymptomatic hyperuricemia and hyperuricemia nephropathy has increased significantly. About 2 / 3 of the uric acid produced by the human body is excreted with the urine through the kidneys. Therefore, hyperuricemia can lead to a decline in renal function. Uric acid nephropathy refers to the short-term deposition of a large number of urate crystals in the renal collecting duct, renal pelvis, and ureter, blocking the renal tub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/519A61P13/12A61P19/06
CPCA61K31/352A61K31/519A61P13/12A61P19/06A61K2300/00
Inventor 徐凌云刘永杰裴忆雪
Owner WUHAN POLYTECHNIC UNIVERSITY
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