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Biomarkers for mortality prognosis in critically ill patients

A technology for biomarkers and patients, applied in biological testing, bioinformatics, biochemical equipment and methods, etc.

Active Publication Date: 2022-08-05
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several immunoassay techniques have been prospectively validated to show differences in results 13，14 , but no clinical tools have been translated into clinical practice

Method used

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  • Biomarkers for mortality prognosis in critically ill patients
  • Biomarkers for mortality prognosis in critically ill patients
  • Biomarkers for mortality prognosis in critically ill patients

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0154] The way to die of dangerous patients

[0155] introduction

[0156] We have previously showed that multiple group analysis is a kind of inhabitant 15 And other diseases (including organ transplantation and exclusion, virus infection, and tuberculosis) The effective way to detect conservative gene expression signals 16-18 Essence Therefore, we assume that multi -group analysis of the results of the results of patients with purulent disease will produce a conservative gene collection, which can steadily predict the results of purulent disease and potentially used as the clinical tool for the prognosis of the disease.

[0157] Materials and methods

[0158] Research design

[0159] The purpose of this study is to analyze multiple gene expression datasets using a comprehensive multi -group meta -analysis framework to identify the genetic set of death of patients with purulent patients at the time of admission. This kind of framework has been described before 15，16，18 Essence

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PUM

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Abstract

Biomarkers and methods of using the same to aid in the diagnosis, prognosis and treatment of critically ill patients are disclosed. In particular, the present invention relates to the use of biomarkers for prognosis of death in critically ill patients suffering from sepsis, severe trauma or burns.

Description

[0001] cross reference [0002] This application requires the equity of the US temporary application in the United States temporarily submitted on June 26, 2016, which is incorporated into this article by reference. [0003] Statement on the research or research on federal government funding [0004] The invention is completed by the government support of the contracts AI057229, AI089859, AI109662, and AI117925 awarded by the National Institute of Health Research. The government has some rights invented. Technical field [0005] The present invention generally involves the prognosis of the risk of death in critical patients. Specifically, the invention involves the purpose of biomarkers, which can be used for the prognosis of death risk of critical patients who have pyunda, severe trauma or burns. Background technique [0006] Pyxiaxia, organ failure caused by new definitions to infected systemic reactions 1 It caused half of the deaths in all hospitals in the United States and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C40B40/06C12Q1/68C40B40/08G01N33/50G01N33/68C12Q1/6883A61P31/04A61P37/02G16B25/00G16B25/20G16B25/10
CPCC12Q1/6883G01N33/6893G16B25/10G16B25/20C40B40/06C40B40/08C12Q2600/158C12Q2600/106G01N2800/20G01N2800/26G01N33/50C12Q2537/165A61P31/04A61P37/02G16B25/00C12Q2600/118
Inventor 普尔威施·卡特里蒂莫西·E·斯威尼
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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