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External preparation for treating eczematous dermatitis and preparation method thereof

An external preparation and a technology for eczema dermatitis, which are applied in the field of external preparations for treating eczema and dermatitis and their preparation, can solve problems such as bacterial and fungal infections, telangiectasia, toxic and side effects, and achieve redness and swelling, inhibition of antibody production, and controllable quality. Effect

Inactive Publication Date: 2019-03-15
GUANGXI XINYE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are following deficiencies in the above technology: 1, long-term use of hormone drugs can produce hormone dependence, causing telangiectasia of skin and mucous membranes and causing systemic toxic and side effects; easy to cause bacterial and fungal infections;
[0005] 2. Traditional external medicines for treating eczema often choose simple Chinese herbal medicines for external use. This method usually takes effect slowly and is prone to rebound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An external preparation for treating eczema dermatitis, the external preparation is a spray, and the spray includes the following raw materials in percentage by weight: 0.01% of rare earth elements, 0.1% of glycyrrhizic acid, 0.001% of astaxanthin, 0.05% of β-cyclodextrin, Refreshing agent 0.001%, the balance of purified water;

[0028] A preparation method of an external preparation for treating eczema dermatitis, characterized in that: comprising the steps of:

[0029] Step 1: Weigh astaxanthin and β-cyclodextrin, add purified water accounting for 30% of the total weight of purified water, perform ultrasonic dispersion at an ultrasonic frequency of 40000 Hz, stir and dissolve at a temperature of 45°C, and obtain solution 1, namely Astaxanthin-β-cyclodextrin inclusion complex solution;

[0030] Step 2: Weigh the cooling agent, pour in the remaining purified water, heat to 60°C to dissolve, and after cooling to room temperature, add rare earth elements to obtain soluti...

Embodiment 2

[0035] An external preparation for treating eczema dermatitis, the external preparation is a spray, and the spray includes the following raw materials in percentage by weight: 0.1% of rare earth elements, 2% of glycyrrhizic acid, 0.05% of astaxanthin, 2% of β-cyclodextrin, Cooling agent 0.01%, the balance of purified water;

[0036] A preparation method of an external preparation for treating eczema dermatitis, characterized in that: comprising the steps of:

[0037] Step 1: Weigh astaxanthin and β-cyclodextrin, add purified water accounting for 50% of the total weight of purified water, perform ultrasonic dispersion at an ultrasonic frequency of 30,000 Hz, stir and dissolve at 100°C, and obtain solution 1, namely Astaxanthin-β-cyclodextrin inclusion complex solution;

[0038] Step 2: Weigh the cooling agent, pour in the remaining purified water, heat to 70°C to dissolve, and after cooling to room temperature, add rare earth elements to obtain solution 2;

[0039] Step 3: Mi...

Embodiment 3

[0043] An external preparation for treating eczema dermatitis, the external preparation is a spray, and the spray includes the following raw materials in percentage by weight: 0.5% of rare earth elements, 5% of glycyrrhizic acid, 1.0% of astaxanthin, 5% of β-cyclodextrin, Cooling agent 0.5%, the balance of purified water;

[0044] A preparation method of an external preparation for treating eczema dermatitis, characterized in that: comprising the steps of:

[0045] Step 1: Weigh astaxanthin and β-cyclodextrin, add purified water accounting for 70% of the total weight of purified water, perform ultrasonic dispersion at an ultrasonic frequency of 20,000 Hz, stir and dissolve at 150°C, and obtain solution 1, namely Astaxanthin-β-cyclodextrin inclusion complex solution;

[0046] Step 2: Weigh the cooling agent, pour in the remaining purified water, heat to 80°C to dissolve, and after cooling to room temperature, add rare earth elements to obtain solution 2;

[0047] Step 3: Mix ...

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PUM

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Abstract

The invention relates to the technical field of preparations, in particular to an external preparation for treating eczematous dermatitis and a preparation method thereof. The external preparation adopts a rare earth element, glycyrrhizic acid, astaxanthin, beta-cyclodextrin and a cooling agent as main components. The components of the external preparation play a synergistic effect, so that the external preparation not only effectively exerts an effect of treating dermatitis of the rare earth element and glycyrrhizic acid and stably exerts an antioxidant effect of astaxanthin, but also has theadvantages of high transdermal efficiency, stable dosage form and the like. The external preparation provided by the invention has a plurality of prevention and treatment effects such as an antiallergic effect, an anti-itching effect and an anti-inflamed effect, has an obvious itching relieving effect, and can be used for treating dermatitis such as eczema, allergic dermatitis, contact dermatitisand psoriasis by inflammation diminishing, itching relieving, sterilization and the like. The preparation method of the external preparation provided by the invention has simple steps, no in vitro cytotoxicity, and is safe and effective, and controllable in quality.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to an external preparation for treating eczema dermatitis and a preparation method thereof. Background technique [0002] Eczema dermatitis is a common skin disease, which seriously affects the life and work of patients. The etiology of eczema is very complicated, which can be simply divided into internal factors and external factors. synergy. External factors such as chemical agents, cosmetics, animal toxins, fish and shrimp, pollen, dust, sun exposure, scratching, etc. Internal factors include genetic factors, mental factors, immune factors, metabolic factors and so on. More and more attention has been paid to the influence of psychological factors on dermatitis and eczema skin diseases. The occurrence of dermatitis and eczema may also have a certain relationship with diet, living rules, and environment. The existing medicines for treating dermatitis are as follows: the Ch...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61K36/61A61K33/244A61K33/24A61K47/69A61K9/12A61P17/00A61P37/08A61P17/04A61P29/00A61P17/06A61P31/04A61P31/10A61P31/02A61K35/583A61K31/122A61K31/045A61K31/704A61K31/22A61K31/225A61K31/16A61K31/44
CPCA61K9/0014A61K9/12A61K31/045A61K31/122A61K31/16A61K31/22A61K31/225A61K31/44A61K31/704A61K33/24A61K35/583A61K36/28A61K36/282A61K36/287A61K36/30A61K36/355A61K36/483A61K36/484A61K36/489A61K36/534A61K36/539A61K36/61A61K36/65A61K36/708A61K36/71A61K36/896A61K36/90A61K47/6951A61P17/00A61P17/04A61P17/06A61P29/00A61P31/02A61P31/04A61P31/10A61P37/08A61K2300/00
Inventor 苏雪
Owner GUANGXI XINYE BIOLOGICAL TECH
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