The present invention discloses a muscle soreness and skin itch treatment drug composition and a preparation method thereof. The drug composition comprises effective medicinal components such as methyl salicylate, camphor, menthol, eucalyptus oil, lavender oil and the like, and an external preparation-acceptable auxiliary component, and is a pharmaceutical agent prepared by using a conventional preparation process, wherein the effective medicinal components concretely comprise, by weight, 15-38% of methyl salicylate, 6-15% of camphor, 8-30% of menthol, 6-20% of eucalyptus oil, and 5-7% of lavender oil. The drug composition has the following functions that: a tendon relaxing and activation effect is provided; muscle and joint pain, camphor on waist and back, sprain, contusion and other symptoms can be relieved and reduced so as to promote rapid corresponding disease recovery; the drug composition contains menthol, camphor, eucalyptus oil and other effective medicinal components so as to provide strong expulsion effects for mosquitoes, flies, wasp and other flying insects, effectively prevent insect biting, and provide effects of anti-inflammation, anti-itching and sterilization; and the drug composition has characteristics of rapid onset, low use amount, and high efficiency.