Supercharge Your Innovation With Domain-Expert AI Agents!

Compound having anti-itching activity

A compound and antioxidant activity technology, applied in the field of pharmaceutical compounds, can solve problems such as large molecular structure, and achieve the effect of moderate molecular weight and stable structure

Inactive Publication Date: 2010-07-28
HEFEI UNIV OF TECH
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its molecular structure is relatively large, so it is not suitable for synthetic medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound having anti-itching activity
  • Compound having anti-itching activity
  • Compound having anti-itching activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]

[0038] synthetic route:

[0039]

[0040]

[0041] Step A: Compound 1 (Ethyl 2-(1H-imidazol-1-yl)acetate)

[0042] Add imidazole (8.17g, 120mmol), TEA (17.34mL, 120mmol), THF (50mL), ethyl chloroacetate (10.56mL, 100mmol) sequentially, reflux and stir for 10h, suction filter after the reaction, and separate the filtrate by column chromatography 12.1 g of yellow liquid was obtained, and the yield was 78.6% (based on ethyl chloroacetate), 1 H NMR (CDCl 3 -d 6 )δ: 7.49(s, 1H), 7.08(s, 1H), 6.94(s, 1H), 4.68(s, 2H), 4.23(q, 2H), 1.25(t, 3H).

[0043] Step B: Compound 2 (2-(1H-imidazol-1-yl)ethanol)

[0044] Add compound 1 (7.71g, 50mmol), methanol (90mL), LiCl (4.24g, 100mmol) in sequence, slowly add NaBH 4 (4.73g, 125mmol), reacted at 50°C for 8h, separated by column chromatography to obtain 4.31g light yellow oil, and the yield was 76.8% (based on compound 1), 1 H NMR (CDCl 3 -d 6 )δ: 7.47 (s, 1H), 7.02 (s, 1H), 6.91 (s, 1H), 4.01 (t, 2H), 3.65 (m, 2H)....

Embodiment 2

[0055] Example 2 ((R)-2-(2-(4-fluorophenyl)acetamido)-3-phenylpropanoic acid-2-(1H-imidazol-1-yl)ethyl ester)

[0056]

[0057] The operation steps are the same as in Example 1, except that in step D, 4-fluorophenylacetic acid is used instead of 4-nitrophenylacetic acid. The final product is a pale yellow oil, 1 H NMR (CDCl 3 -d 6 )δ: 6.84~7.43 (m, 12H), 4.76 (m, 1H), 4.29 (t, 2H), 4.12 (t, 2H), 3.49 (s, 2H), 2.94 (dd, 2H).

Embodiment 3

[0058] Example 3 ((R)-2-(2-(4-methylphenyl)acetamido)-3-phenylpropanoic acid-2-(1H-imidazol-1-yl)ethyl ester)

[0059]

[0060] The operation steps are the same as in Example 1, and in step D, 4-methylphenylacetic acid is used instead of 4-nitrophenylacetic acid. The final product is a pale yellow oil, 1 H NMR (CDCl 3 -d 6 )δ: 6.81~7.35(m, 12H), 4.75(m, 1H), 4.21(t, 2H), 4.08(t, 2H), 3.49(s, 2H), 2.95(dd, 2H), 2.34(s , 3H).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel compound having an anti-itching activity, which is as shown in general formula (I) and has obvious anti-itching activity. The invention also relates to a method for preparing the compound and intermediate products thereof.

Description

1. Technical field [0001] The present invention relates to a pharmaceutical compound, in particular to a compound with antioxidant activity. 2. Background technology: [0002] Pruritus is an unpleasant feeling that can cause the desire to scratch. It is also a response mechanism for self-protection in the physiological state of the body, just like warmth, heat, and pain. It is generally caused by skin diseases, biliary tract diseases, thyroid diseases, kidney diseases, malignant tumors and AIDS. According to reports, there were 300 million cases of scabies alone in 2006, and chronic itching caused by lung disease, kidney disease, and hereditary dermatitis is a medical problem, especially itching caused by tumors, which is difficult to understand. Tolerance, routine medical treatment is difficult to detect abnormalities, and the existing antipruritic drugs have no significant curative effect, which seriously affects the quality of life of patients. At the same time, the tra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D233/60C07D403/12A61P17/04
Inventor 姚日生江来恩徐峻邓胜松刘璐李婷婷
Owner HEFEI UNIV OF TECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com