Multi-color fluorescent excitation and detection device and nucleic acid analysis apparatus employing same

A technology of fluorescence excitation and detection device, which is applied in material excitation analysis, fluorescence/phosphorescence, biochemical cleaning device, etc., and can solve problems such as being unsuitable for isothermal amplification devices.

Pending Publication Date: 2019-03-19
DELTA ELECTRONICS INTL SINGAPORE
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Problems solved by technology

More importantly, most devices using isothermal amplification prefer mobile detection environments, so the system needs to be highly integrated. Therefo

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  • Multi-color fluorescent excitation and detection device and nucleic acid analysis apparatus employing same
  • Multi-color fluorescent excitation and detection device and nucleic acid analysis apparatus employing same
  • Multi-color fluorescent excitation and detection device and nucleic acid analysis apparatus employing same

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[0060] Some typical embodiments embodying the features and advantages of the present invention will be described in detail in the following description. It should be understood that the present invention can have various changes in different schemes, which do not depart from the scope of the present invention, and the description and drawings therein are essentially for illustrative purposes, rather than limiting the present invention.

[0061] The present invention provides a nucleic acid analysis device with isothermal amplification applications. Furthermore, the present invention provides a nucleic acid analysis device that integrates a fluid delivery unit, a temperature control unit, a rotation drive unit, and a multicolor fluorescence excitation and detection device On a single device, nucleic acid analysis can be performed on a single device to achieve the functions of sample purification, nucleic acid extraction, nucleic acid diffusion, and nucleic acid detection.

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Abstract

A multi-color fluorescent excitation and detection device is disclosed and includes at least one illumination module, a cartridge and at least one detection module. The at least one illumination module provides an illumination light at specified range of wavelengths. The cartridge comprises a detection chip comprising plural detection wells arranged around the peripheral of the detection chip. Each of the detection wells is accommodated a corresponding fluorescent dye therein. Each of the detection wells includes a first wall and a second wall. The illumination light transmits through the first wall to illuminate on the fluorescent sample so as to excite a fluorescent signal, and the fluorescent signal generated from the fluorescent sample transmits through the second wall. The at least one detection module receives the fluorescent signal and converts the fluorescent signal to an electrical signal.

Description

Technical field [0001] The present invention relates to a fluorescence detection device, in particular to a multicolor fluorescence excitation and detection device, and a nucleic acid analysis equipment using the multicolor fluorescence excitation and detection device. Background technique [0002] In order to obtain a large number of specific fragments of DNA in response to different needs, the methods have been booming in recent years. Scientists have been striving to find efficient ways to meet their goals, and polymerase chain reaction (PCR) is one of them. This is the most economical and rapid technology that can obtain one billion copies of specific DNA fragments in a short time. PCR technology can be applied in a variety of fields, such as selective DNA isolation for genetic identification, forensic analysis of ancient DNA in archaeology, genetic testing and medical applications of tissue types, rapid and accurate infectious diseases in hospitals and research institutions ...

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Application Information

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IPC IPC(8): G01N21/64C12M1/38C12M1/34C12M1/00
CPCC12Q1/68C12Q1/6806G01N21/64C12Q2563/107
Inventor 马勃梁骞游杰颖
Owner DELTA ELECTRONICS INTL SINGAPORE
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