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Preparation method and anti-malarial application of dobinea plant extract and medicine composition of dobinea plant extract

A kind of plant extract and extract technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problem of unseen plant extracts of the genus Nine Pterodactyl, and achieve good anti-malarial effect

Inactive Publication Date: 2019-03-22
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are no reports on the preparation method of the extract of the plant of the genus Chiazimu, the drug combination with the extract as the active ingredient, and its application in anti-malarial

Method used

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  • Preparation method and anti-malarial application of dobinea plant extract and medicine composition of dobinea plant extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of Gastrodia elata extract of the present invention:

[0021] Naturally dry the root of Gastrodia elata plant, crush it to 20-30 mesh, and use 75% ethanol at 95 o Under the condition of C, reflux extraction was carried out 3 times, each time for 2 h, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain the extract.

Embodiment 2

[0023] Antimalarial activity detection of the extract of the present invention:

[0024] Using the internationally accepted 4-day inhibition test method, each mouse was inoculated intraperitoneally with 1×10 7 Plasmodium-infected red blood cells were given intragastric administration 3 hours after inoculation with Plasmodium, and then administered once every 24 hours for 4 consecutive days (the inoculation day was D 0 , the next day is D 1 , and so on), on day 5 (D 4 ) blood from the tail vein, coated with a thin blood film, fixed in methanol, stained with Wright-Giemsa mixed staining method, and observed under a 10×100 oil microscope. If no Plasmodium asexual body is found after randomly checking 50 fields of view, it is judged as negative, and the positive thin blood film is randomly counted in 5 fields of view, and the total number of red blood cells is not less than 1000, and then the inhibition rate of Plasmodium is calculated according to the following formula .

[0...

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Abstract

The invention relates to application of a dobinea plant extract to the preparation of an anti-malarial product and belongs to the pharmaceutical fields of traditional Chinese medicines and natural medicines. The medicine composition is an anti-malarial medicine with the extract as an active ingredient. The application of the dobinea plant extract, provided by the invention, has the benefits that the indication of a dobinea plant medicinal material is expanded, and the medicinal value of the dobinea plant medicinal material is improved.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of an extract from a plant of the genus Cooperia, a drug combination with the extract as an active ingredient, and its application in antimalarial agents. technical background: [0002] Nine children ( Dobinea ) plants belong to Anacardiaceae or Podoaceae, and are shrubs or perennial subshrub-like herbs with hypertrophic rhizomes. There are 2 species in the world, Gastrodia chinensis ( Dobinea delavayi (Baill.) Baill.) and Gongshan Jiuzimu ( D. vulgaris Buch.-Ham. ex D. Don), all produced in my country. Gastrodia chinensis is a perennial subshrub-like herb with thick rhizomes. It is named after it is shaped like a horn after processing; it is produced in the central to northwestern part of Yunnan and southwestern Sichuan; it grows in sunny grass slopes or shrubs at an altitude of 1100-2300 meters . ...

Claims

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Application Information

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IPC IPC(8): A61K36/22A61P33/06
CPCA61K36/22A61K2236/333A61K2236/35A61P33/06
Inventor 姜北肖朝江陈浩沈怡董相沈磊
Owner DALI UNIV
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