Application of radix plumbaginis zeylanicae to preparation of drug for treating pulmonary fibrosis disease

A technology for pulmonary fibrosis and Baihuadan, which is applied to the field of Baihuadan for preparing medicines for treating pulmonary fibrosis diseases, can solve the problems of high toxicity of cyclophosphamide, inaccurate curative effect, damage to liver function and the like, and achieves no toxic and side effects. , Conducive to the promotion, the effect of inhibiting proliferation

Active Publication Date: 2019-03-26
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucocorticoids often need to be used in large doses and for a long time, which may inhibit the normal immune response of the body and lead to infection; azathioprine is well tolerated, but it is easy to cause bone marrow suppression; cyclophosphamide has a high toxicity, which not only causes bone

Method used

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  • Application of radix plumbaginis zeylanicae to preparation of drug for treating pulmonary fibrosis disease
  • Application of radix plumbaginis zeylanicae to preparation of drug for treating pulmonary fibrosis disease
  • Application of radix plumbaginis zeylanicae to preparation of drug for treating pulmonary fibrosis disease

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Effect test

Embodiment 1

[0029] An embodiment of the preparation method of the plumbago extract of the present invention, the preparation method of the plumbago extract comprises the following steps:

[0030] (1) Take fresh plum blossom stems, cut them into small pieces of about 3-6 cm, and dry them at 60°C for 24 hours;

[0031] (2) Adding ethanol with a volume fraction of 90% to the dry plumflower stem, soaking and extracting for 2 days, filtering, and collecting the filtrate; adding ethanol with a volume fraction of 90% to the filter residue, continuing soaking and extracting for 2 days, filtering, and collecting filtrate;

[0032] (3) Combine the two filtrates in step (2), concentrate the filtrate at 58° C. using a rotary evaporator, and dry the obtained concentrate at 50° C. in a negative pressure drying oven to obtain the plumbago extract.

Embodiment 2

[0034] An embodiment of the preparation method of the plumbago extract of the present invention, the preparation method of the plumbago extract comprises the following steps:

[0035] (1) Take fresh plum blossom leaves, cut into small pieces of about 3-6cm, and dry at 55°C for 48h;

[0036] (2) Adding ethanol with a volume fraction of 70% to the dry plumflower stem, soaking and extracting for 4 days, filtering, and collecting the filtrate; adding ethanol with a volume fraction of 70% to the filter residue, continuing soaking and extracting for 4 days, filtering, collecting filtrate;

[0037] (3) Combine the two filtrates in step (2), concentrate the filtrate at 60° C. with a rotary evaporator, and dry the obtained concentrate at 60° C. with a negative pressure drying oven to obtain the plumbago extract.

Embodiment 3

[0039] An embodiment of the preparation method of the plumbago extract of the present invention, the preparation method of the plumbago extract comprises the following steps:

[0040] (1) Take fresh plumbago stems and leaves, cut them into small pieces of about 3-6cm, and dry them at 50°C for 35h;

[0041] (2) Adding ethanol with a volume fraction of 80% to the dried plumflower stems and leaves, soaking and extracting for 3 days, filtering, and collecting the filtrate; adding ethanol with a volume fraction of 80% to the filter residue, continuing soaking and extracting for 3 days, filtering , collect the filtrate;

[0042] (3) Combine the two filtrates in step (2), concentrate the filtrate at 50° C. using a rotary evaporator, and dry the obtained concentrate at 50° C. in a negative pressure drying oven to obtain the plumbago extract.

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Abstract

The invention discloses application of radix plumbaginis zeylanicae to the preparation of a drug for treating a pulmonary fibrosis disease. The invention also discloses the drug for treating the pulmonary fibrosis disease. The drug is prepared from the radix plumbaginis zeylanicae and a pharmaceutically acceptable carrier. Discovered for the first time by the inventor of the application, the radixplumbaginis zeylanicae can be used for obviously inhibiting the proliferation of a fibroblast of pulmonary tissue, and can be used for effectively treating the interstitial fibrosis of the pulmonarytissue. The drug provided by the invention is low in cost, has no toxic and side effects, has an obvious curative effect on the pulmonary fibrosis disease, and is short in treatment period and beneficial to popularization.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the use of plumbago dan in the preparation of medicines for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a type of interstitial lung disease, mainly involving the pulmonary interstitium, alveoli and (or) bronchioles, with the proliferation of fibroblasts (Fb) and a large amount of extracellular matrix (ECM) It is characterized by aggregation, and the course of the disease progresses slowly, gradually losing alveolar-capillary functional units, and eventually develops into diffuse pulmonary fibrosis and honeycombing, leading to respiratory failure and death. Various factors can cause pulmonary fibrosis, such as occupational dust (SiO 2 etc.), radiation injury and some drugs (bleomycin), etc., in addition to a type of pulmonary fibrosis of unknown etiology - idiopathic pulmonary fibrosis (idiopathicpulmonary...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P11/00A61K135/00A61K127/00
CPCA61K36/185A61K2236/333A61K2236/39A61K2236/51A61P11/00
Inventor 李洪涛
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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